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Tuberculosis

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The Prokaryotes

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Abstract

Mycobacterium tuberculosis is an obligate human pathogen of immense importance, infecting up to one third of the human population and causing 1.4 million deaths per year. Despite a long-established vaccine and initially effective antibiotics, M. tuberculosis continues to be a scourge of mankind through a combination of factors: related to the organism, host, their interaction, co-infections such as with HIV, and societal issues. The hallmark of M. tuberculosis as a pathogen is its intracellular growth and ability to evade killing by macrophages, including latent infection for many years. Here we consider distinctive characteristics of the organism, pathogenesis, epidemiology, clinical syndrome, diagnosis, treatment, and prevention of tuberculosis. Pressing challenges include combating drug resistance, designing better vaccines, improved diagnostics, and simplified treatment regimes. Molecular techniques are increasingly being transferred from bench to bedside and the coordinated efforts of microbiologists, immunologists, epidemiologists, clinicians, and policy-makers are required to turn the tide against tuberculosis.

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Authors and Affiliations

  1. Imperial College London, London, UK

    Robindra Basu Roy

  2. Harvard School of Public Health, Boston, USA

    Eric Rubin

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  1. Robindra Basu Roy
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  2. Eric Rubin
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Correspondence to Eric Rubin .

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Editors and Affiliations

  1. Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv, Israel

    Eugene Rosenberg

  2. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

    Edward F. DeLong

  3. Department of Microbiology and Immunology, Harvard Medical School, Boston, MA, USA

    Stephen Lory

  4. Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany

    Erko Stackebrandt

  5. Laboratory of Microbiology, Institute of Biology, Center for Health Sciences, Federal University of Rio de Janeiro (UFRJ), Ilha do Fundão, Rio de Janeiro, Brazil

    Fabiano Thompson

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Roy, R.B., Rubin, E. (2013). Tuberculosis. In: Rosenberg, E., DeLong, E.F., Lory, S., Stackebrandt, E., Thompson, F. (eds) The Prokaryotes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30144-5_93

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