• Narveen Jandu
  • Marcia B. Goldberg
Reference work entry


Dysentery is bloody diarrhea caused by infection with certain bacteria or parasites. The most common bacterial causes are members of the Genus Shigella. Shigella are Gram-negative intracellular bacterial pathogens that cause diarrheal disease by infecting intestinal epithelial cells. Following invasion of intestinal cells, Shigella induce host cell cytoskeletal rearrangements and interfere with host cell signal transduction cascades. These effects are mediated by multiple different effector proteins that are translocated from the bacterial cell into the host cell through a type three secretion system. Translocated Shigella effector proteins modulate the host immune response, which contributes to inflammation during infection and to clearance of the organism. Antibiotics are available and effective against Shigella infection; however, isolates resistant to routine antibiotics are increasingly frequent in many areas of the world. Vaccine development is an ongoing area of research.


Effector Protein Virulence Plasmid Host Epithelial Cell Bacterial Cell Envelope Shigella Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Narveen Jandu
    • 1
  • Marcia B. Goldberg
    • 1
    • 2
  1. 1.Department of Microbiology and ImmunobiologyHarvard Medical SchoolBostonUSA
  2. 2.Division of Infectious Diseases, Department of MedicineMassachusetts General HospitalBostonUSA

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