Quorum Sensing

  • Bonnie L. Bassler
  • Melissa B. Miller


Bacteria have an exquisite ability to sense and adapt to a constantly fluctuating environment. They have evolved the capacity to detect a variety of temporal and spatial cues, and in response to such stimuli, bacteria initiate signal transduction cascades that culminate in changes in gene expression. The ability to rapidly alter gene expression, and consequently behavior, in response to a dynamic environment presumably gives bacteria the plasticity to survive in rich, neutral, and hostile situations.


Quorum Sensing Homoserine Lactone Pseudomonas Quinolone Signal Cell Population Density LuxR Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Ahmer BMM, Van Reeuwijk J, Timmers CD, Valentine PJ, Heffron F (1998) Salmonella typhimurium encodes an sdiA homolog, a putative quorum sensor of the luxR family, that regulates genes on the virulence plasmid. J Bacteriol 180:1185–1193PubMedGoogle Scholar
  2. Atkinson S, Throup JP, Stewart GSAB, Williams P (1999) A hierarchical quorum-sensing system in Yersinia pseudotuberculosis is involved in the regulation of motility and clumping. Mol Microbiol 33:1267–1277PubMedCrossRefGoogle Scholar
  3. Bainton NJ, Bycroft BW, Chhabra SR, Stead P, Gledhill L, Hill PJ, Rees CED, Winson MK, Salmond GPC, Stewart GSAB, Williams P (1992) A general role for the lux autoinducer in bacterial cell signalling: control of antibiotic biosynthesis in Erwinia. Gene 116:87–91PubMedCrossRefGoogle Scholar
  4. Bassler BL (1999a) A multichannel two-component signaling relay controls quorum sensing in Vibrio harveyi. In: Dunny GM, Winans SC (eds) Cell-cell signaling in bacteria. ASM Press, Washington, DC, pp 259–276Google Scholar
  5. Bassler BL (1999b) How bacteria talk to each other: regulation of gene expression by quorum sensing. Curr Opin Microbiol 2:582–587PubMedCrossRefGoogle Scholar
  6. Bassler BL, Wright M, Showalter RE, Silverman MR (1993) Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence. Mol Microbiol 9:773–786PubMedCrossRefGoogle Scholar
  7. Bassler BL, Wright M, Silverman MR (1994a) Multiple signalling systems controlling gene expression of luminescence in Vibrio harveyi: sequence and function of genes encoding a second sensory pathway. Mol Microbiol 13:273–286PubMedCrossRefGoogle Scholar
  8. Bassler BL, Wright M, Silverman M (1994b) Sequence and function of luxO, a negative regulator of luminescence in Vibrio harveyi. Mol Microbiol 12:403–412PubMedCrossRefGoogle Scholar
  9. Bassler BL, Greenberg EP, Stevens AM (1997) Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi. J Bacteriol 179:4043–4045PubMedGoogle Scholar
  10. Beck von Bodman S, Farrand SK (1995) Capsular polysaccharide biosynthesis and pathogenicity in Erwinia stewartii require induction by an n-acylhomoserine lactone autoinducer. J Bacteriol 177:5000–5008PubMedGoogle Scholar
  11. Cao J-G, Meighen EA (1989) Purification and structural identification of an autoinducer for the luminescence system of Vibrio harveyi. J Biol Chem 264:21670–21676PubMedGoogle Scholar
  12. Chernin LS, Winson MK, Thompson JM, Haran S, Bycroft BW, Chet I, Williams P, Stewart GSAB (1998) Chitinolytic activity in Chromobacterium violaceum: substrate analysis and regulation by quorum sensing. J Bacteriol 180:4435–4441PubMedGoogle Scholar
  13. Cubo MT, Economou A, Murphy G, Johnston AWB, Downie JA (1992) Molecular characterization and regulation of the rhizosphere-expressed genes rhiABCR that can influence nodulation by Rhizobium leguminosarum biovar viciae. J Bacteriol 174:4026–4035PubMedGoogle Scholar
  14. Davies DG, Parsek MR, Pearson JP, Iglewski BH, Costerton JW, Greenberg EP (1998) The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science 280:295–298PubMedCrossRefGoogle Scholar
  15. Davis JM, Mayor J, Plamann L (1995) A missense mutation in rpoD results in an A-signalling defect in Myxococcus xanthus. Mol Microbiol 18:943–952PubMedCrossRefGoogle Scholar
  16. De Kievit TR, Iglewski BH (2000) Bacterial quorum sensing in pathogenic relationships. Infect Immun 68:4839–4849PubMedCrossRefGoogle Scholar
  17. Dong Y, Xu J, Li X, Zhang L (2000) AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora. Proc Natl Acad Sci 97:3526–3531PubMedCrossRefGoogle Scholar
  18. Dworkin M (1973) Cell-cell interactions in the myxobacteria. Symp Soc Gen Microbiol 23:125–147Google Scholar
  19. Dworkin M, Kaiser D (1985) Cell interactions in myxobacterial growth and development. Science 230:18–24PubMedCrossRefGoogle Scholar
  20. Eberhard A, Burlingame AL, Eberhard C, Kenyon GL, Nealson KH, Oppenheimer NJ (1981) Structural identification of autoinducer of Photobacterium fischeri. Biochemistry 20:2444–2449PubMedCrossRefGoogle Scholar
  21. Eberl L, Winson MK, Sternberg C, Stewart GSAB, Christiansen G, Chhabra SR, Bycroft B, Williams P, Molin S, Givskov M (1996) Involvement of n-acyl-l-homoserine lactone autoinducers in controlling the multicellular behavior of Serratia liquefaciens. Mol Microbiol 20:127–136PubMedCrossRefGoogle Scholar
  22. Engebrecht J, Silverman M (1984) Identification of genes and gene products necessary for bacterial bioluminescence. Proc Natl Acad Sci 81:4154–4158PubMedCrossRefGoogle Scholar
  23. Engebrecht J, Silverman M (1987) Nucleotide sequence of the regulatory locus controlling expression of bacterial genes for bioluminescence. Nucleic Acids Res 15:10455–10467PubMedCrossRefGoogle Scholar
  24. Engebrecht J, Nealson K, Silverman M (1983) Bacterial bioluminescence: isolation and genetic analysis of functions from Vibrio fischeri. Cell 32:773–781PubMedCrossRefGoogle Scholar
  25. Evans K, Passador L, Ramakrishnan S, Tsang E, Nezezon J, Poole K (1998) Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa. J Bacteriol 180:5443–5447PubMedGoogle Scholar
  26. Flavier AB, Ganova-Raeva LM, Schell MA, Denny TP (1997) Hierarchical autoinduction in Ralstonia solanacearum: control of acyl-homoserine lactone production by a novel autoregulatory system responsive to 3-hydroxypalmitic acid methyl ester. J Bacteriol 179:7089–7097PubMedGoogle Scholar
  27. Freeman JA, Bassler BL (1999a) A genetic analysis of the function of luxO, a two-component response regulator involved in quorum sensing in Vibrio harveyi. Mol Microbiol 31:665–677PubMedCrossRefGoogle Scholar
  28. Freeman JA, Bassler BL (1999b) Sequence and function of luxU: a two-component phosphorelay protein that regulates quorum sensing in Vibrio harveyi. J Bacteriol 181:899–906PubMedGoogle Scholar
  29. Freeman JA, Lilley BN, Bassler BL (2000) A genetic analysis of the functions of luxN: a two-component hybrid sensor kinase that regulates quorum sensing in Vibrio harveyi. Mol Microbiol 35:139–149PubMedCrossRefGoogle Scholar
  30. Fuqua C, Eberhard A (1999) Signal generation in autoinduction systems: synthesis of acylated homoserine lactones by luxI-type proteins. In: Dunny GM, Winans SC (eds) Cell-cell signaling in bacteria. ASM Press, Washington, DC, pp 211–230Google Scholar
  31. Fuqua C, Winans SC, Greenberg EP (1996) Census and consensus in bacterial ecosystems: the luxR-luxI family of quorum-sensing transcriptional regulators. Annu Rev Microbiol 50:727–751PubMedCrossRefGoogle Scholar
  32. Garcia-Lara J, Shang LH, Rothfield LI (1996) An extracellular factor regulates expression of sdiA, a transcriptional activator of cell division genes in Escherichia coli. J Bacteriol 178:2742–2748PubMedGoogle Scholar
  33. Gilson L, Kuo A, Dunlap PV (1995) AinS and a new family of autoinducer synthesis proteins. J Bacteriol 177:6946–6951PubMedGoogle Scholar
  34. Givskov M, De Nys R, Manefield M, Gram L, Maximilien R, Eberl L, Molin S, Steinberg PD, Kjelleberg S (1996) Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling. J Bacteriol 178:6618–6622PubMedGoogle Scholar
  35. Givskov M, Eberl L, Molin S (1997) Control of exoenzyme production, motility and cell differentiation in Serratia liquefaciens. FEMS Microbiol Lett 148:115–122CrossRefGoogle Scholar
  36. Gorski L, Gronewold T, Kaiser D (2000) A sigma(54) activator protein necessary for spore differentiation within the fruiting body of Myxococcus xanthus. J Bacteriol 182:2438–2444PubMedCrossRefGoogle Scholar
  37. Gray KM, Passador L, Iglewski BH, Greenberg EP (1994) Interchangeability and specificity of components from the quorum-sensing regulatory systems of Vibrio fischeri and Pseudomonas aeruginosa. J Bacteriol 176:3076–3080PubMedGoogle Scholar
  38. Gray KM, Pearson JP, Downie JA, Boboye BEA, Greenberg EP (1996) Cell-to-cell signaling in the symbiotic nitrogen-fixing bacterium Rhizobium leguminosarum: autoinduction of a stationary phase and rhizosphere-expressed genes. J Bacteriol 178:372–376PubMedGoogle Scholar
  39. Hagen DC, Bretcher AP, Kaiser D (1978) Synergism between morphogenetic mutants of Myxococcus xanthus. Dev Biol 64:284–296PubMedCrossRefGoogle Scholar
  40. Hanzelka BL, Greenberg EP (1996) Quorum sensing in Vibrio fischeri: evidence that s-adenosylmethionine is the amino acid substrate for autoinducer synthesis. J Bacteriol 178:5291–5294PubMedGoogle Scholar
  41. Havarstein LS, Morrison DA (1999) Quorum sensing and peptide pheromones in streptococcal competence for genetic transformation. In: Dunny GM, Winans SC (eds) Cell-cell signaling in bacteria. ASM Press, Washington, DC, pp 9–26Google Scholar
  42. Jones S, Yu B, Bainton NJ, Birdsall M, Bycroft BW, Chhabra SR, Cox AJR, Golby P, Reeves PJ, Stephens S, Winson MK, Salmond GPC, Stewart GSAB, Williams P (1993) The lux autoinducer regulates the production of exoenzyme virulence determinants in Erwinina carotovora and Pseudomonas aeruginosa. EMBO J 12:2477–2482PubMedGoogle Scholar
  43. Kaplan HB, Greenberg EP (1985) Diffusion of autoinducer is involved in regulation of the Vibrio fischeri luminescence system. J Bacteriol 163:1210–1214PubMedGoogle Scholar
  44. Kaplan HB, Kupsa A, Kaiser D (1991) Suppressors that permit A-signal-independent developmental gene expression in Myxococcus xanthus. J Bacteriol 173:1460–1470PubMedGoogle Scholar
  45. Kim SY, Lee SE, Kim YR, Kim JH, Ryu PY, Chung SS, Rhee JH (2000) Virulence regulatory role of luxS quorum sensing system in Vibrio vulnificus. In: Abstract, ASM general meeting, Los Angeles, CA.Abstract B-248Google Scholar
  46. Kleerebezem M, Quadri LEN, Kuipers OP, de Vos WM (1997) Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria. Mol Microbiol 25:895–904CrossRefGoogle Scholar
  47. Kuo A, Blough NV, Dunlap PV (1994) Multiple n-acyl-l-homoserine lactone autoinducers of luminescence in the marine symbiotic bacterium Vibrio fischeri. J Bacteriol 176:7558–7565PubMedGoogle Scholar
  48. Kupsa A, Plamann L, Kaiser D (1992a) A-signalling and the cell density requirement for Myxococcus xanthus development. J Bacteriol 174:7360–7369Google Scholar
  49. Kupsa A, Plamann L, Kaiser D (1992b) Identification of heat-stable A-factor from Myxococcus xanthus. J Bacteriol 174:3319–3326Google Scholar
  50. LaRossa R, Kuner J, Hagen D, Manoil C, Kaiser D (1983) Developmental cell interactions of Myxococcus xanthus: analysis of mutants. J Bacteriol 153:1394–1404PubMedGoogle Scholar
  51. Latifi A, Foglino M, Tanaka K, Williams P, Luzdunski A (1996) A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhlR to expression of the stationary-phase sigma factor rpoS. Mol Microbiol 21:1137–1146PubMedCrossRefGoogle Scholar
  52. Lazazzera BA, Grossman AD (1998) The ins and outs of peptide signaling. Trends Microbiol 6:288–294PubMedCrossRefGoogle Scholar
  53. Lazazzera BA, Palmer T, Quisel J, Grossman AD (1999) Cell-density control of gene expression and development in Bacillus subtilis. In: Dunny GM, Winans SC (eds) Cell-cell signaling in bacteria. ASM Press, Washington, DC, pp 27–46Google Scholar
  54. Lee K-H, Ruby EG (1994) Effect of the squid host on the abundance and distribution of symbiotic Vibrio fischeri in nature. Appl Environ Microbiol 60:1565–1571PubMedGoogle Scholar
  55. Lewenza S, Conway B, Greenberg EP, Sokol PA (1999) Quorum sensing in Burkholderia cepacia: identification of the luxRI homologs CepRI. J Bacteriol 181:748–756PubMedGoogle Scholar
  56. Lithgow JK, Wilkinson A, Hardman A, Rodelas B, Wisniewski-Dye F, Williams P, Downie JA (2000) The regulatory locus cinRI in Rhizobium leguminosarum controls a network of quorum-sensing loci. Mol Microbiol 37:81–97PubMedCrossRefGoogle Scholar
  57. Luo Z, Qin Y, Farrand S (2000) The antiactivator TraM interferes with the autoinducer-dependent binding of TraR to DNA by interacting with the C-terminal region of the quorum-sensing activator. J Biol Chem 275:7713–7722PubMedCrossRefGoogle Scholar
  58. Manefield M, de Nys R, Kumar N, Read R, Givskov M, Steinberg P, Kjelleberg S (1999) Evidence that halogated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein. Microbiology 145:283–291PubMedCrossRefGoogle Scholar
  59. Martin M, Showalter R, Silverman M (1989) Identification of a locus controlling expression of luminescence genes in Vibrio harveyi. J Bacteriol 171:2406–2414PubMedGoogle Scholar
  60. Mayville P, Ji G, Beavis R, Yang H, Goger M, Novick RP, Muir TW (1999) Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence. Proc Natl Acad Sci 96:1218–1223PubMedCrossRefGoogle Scholar
  61. McClean KH, Winson MK, Fish L, Taylor A, Chhabra SR, Camara M, Daykin M, Lamb JH, Swift S, Bycroft BW, Stewart GSAB, Williams P (1997) Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of n-acylhomoserine lactones. Microbiology 143:3703–3711PubMedCrossRefGoogle Scholar
  62. McKnight SL, Iglewski BH, Pesci EC (2000) The Pseudomonas quinolone signal regulates Rhl quorum sensing in Pseudomonas aeruginosa. J Bacteriol 182:2702–2708PubMedCrossRefGoogle Scholar
  63. Milton DL, Hardman A, Camara M, Chhabra SR, Bycroft BW, Stewart GSAB, Williams P (1997) Quorum sensing in Vibrio anguillarum: characterization of the vanI/vanR locus and identification of the autoinducer n-(3-oxodecanoyl)-l-homoserine lactone. J Bacteriol 179:3004–3012PubMedGoogle Scholar
  64. Miyamoto CM, Lin YH, Meighen EA (2000) Control of bioluminescence in Vibrio fischeri by the luxO signal response regulator. Mol Microbiol 36:594–607PubMedCrossRefGoogle Scholar
  65. More MI, Finger LD, Stryker JL, Fuqua C, Eberhard A, Winans SC (1996) Enzymatic synthesis of a quorum sensing autoinducer through use of defined substrates. Science 272:1655–1658PubMedCrossRefGoogle Scholar
  66. Morfeldt E, Tegmark K, Arvidson S (1996) Transcriptional control of the agr-dependent virulence gene regulator, RNAIII, in Staphylococcus aureus. Mol Microbiol 21:1227–1237PubMedCrossRefGoogle Scholar
  67. Nasser W, Bouillant ML, Salmond G, Reverchon S (1998) Characterization of the Erwinia chrysanthemi ExpI-ExpR locus directing the synthesis of two n-acyl-homoserine lactone signal molecules. Mol Microbiol 29:1391–1405PubMedCrossRefGoogle Scholar
  68. Novick RP (1999) Regulation of pathogenicity in Staphylococcus aureus by a peptide-based density-sensing system. In: Dunny GM, Winans SC (eds) Cell-cell signaling in bacteria. ASM Press, Washington, DC, pp 129–146Google Scholar
  69. Ochsner UA, Reiser J (1995) Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. Proc Natl Acad Sci 92:6424–6428PubMedCrossRefGoogle Scholar
  70. Parkinson JS (1995) Genetic approaches for signaling pathways and proteins. In: Hoch JA, Silhavy TJ (eds) Two-component signal transduction. ASM Press, Washington, DC, pp 9–24Google Scholar
  71. Parsek MR, Val DL, Hanzelka BL, Cronan JE Jr, Greenberg EP (1999) Acyl homoserine-lactone quorum-sensing signal generation. Proc Natl Acad Sci 96:4360–4365PubMedCrossRefGoogle Scholar
  72. Passador L, Cook JM, Gambello MJ, Rust L, Iglewski BH (1993) Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Science 260:1127–1130PubMedCrossRefGoogle Scholar
  73. Pearson JP, Gray KM, Passador L, Tucker KD, Eberhard A, Iglewski BH, Greenberg EP (1994) Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc Natl Acad Sci 91:197–201PubMedCrossRefGoogle Scholar
  74. Pearson JP, Passador L, Iglewski BH, Greenberg EP (1995) A second n-acylhomoserine lactone signal produced by Pseudomonas aeruginosa. Proc Natl Acad Sci 92:1490–1494PubMedCrossRefGoogle Scholar
  75. Pesci EC, Iglewski BH (1997) The chain of command in Pseudomonas quorum sensing. Trends Microbiol 2:132–134CrossRefGoogle Scholar
  76. Pesci EC, Iglewski BH (1999) Quorum sensing in Pseudomonas aeruginosa. In: Dunny GM, Winans SC (eds) Cell-cell signaling in bacteria. ASM Press, Washington, DC, pp 147–155Google Scholar
  77. Pesci EC, Milbank JBJ, Pearson JP, McKnight S, Kende AS, Greenberg EP, Iglewski BH (1999) Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Proc Natl Acad Sci 96:11229–11234PubMedCrossRefGoogle Scholar
  78. Pierson LS III, Keppenne VD, Wood DW (1994) Phenazine antibiotic biosynthesis in Pseudomonas aureofaciens 30-84 is regulated by phzR in response to cell density. J Bacteriol 176:3966–3974PubMedGoogle Scholar
  79. Pierson LS III, Wood DW, Beck von Bodman S (1999) Quorum sensing in plant-associated bacteria. In: Dunny GM, Winans SC (eds) Cell-cell signaling in bacteria. ASM Press, Washington, DC, pp 101–115Google Scholar
  80. Piper KR, Beck von Bodman S, Farrand SK (1993) Conjugation factor of Agrobacterium tumefaciens regulates Ti plasmid transfer by autoinduction. Nature 362:448–450PubMedCrossRefGoogle Scholar
  81. Pirhonen M, Flego D, Heikinheimo R, Palva ET (1993) A small diffusible signal molecule is responsible for the global control of virulence and exoenzyme production in the plant pathogen Erwinia carotovora. EMBO J 12:2467–2476PubMedGoogle Scholar
  82. Plamann L, Kuspa A, Kaiser D (1992) Proteins that rescue A-signal-defective mutants of Myxococcus xanthus. J Bacteriol 174:3311–3318PubMedGoogle Scholar
  83. Plamann L, Davis JM, Cantwell B, Mayor J (1994) Evidence that asgB encodes a DNA-binding protein essential for growth and development of Myxococcus xanthus. J Bacteriol 176:2013–2020PubMedGoogle Scholar
  84. Plamann L, Li Y, Cantwell B, Mayor J (1995) The Myxococcus xanthus asgA gene encodes a novel signal transduction protein required for multicellular development. J Bacteriol 177:2014–2020PubMedGoogle Scholar
  85. Puskas A, Greenberg EP, Kaplan S, Schaefer AL (1997) A quorum-sensing system in the free-living photosynthetic bacterium Rhodobacter sphaeroides. J Bacteriol 179:7530–7537PubMedGoogle Scholar
  86. Reverchon S, Bouillant ML, Salmond G, Nasser W (1998) Integration of the quorum-sensing system in the regulatory networks controlling virulence factor synthesis in Erwinia chrysanthemi. Mol Microbiol 29:1407–1418PubMedCrossRefGoogle Scholar
  87. Rodelas B, Lithgow JK, Wisniewski-Dye F, Hardman A, Wilkinson A, Economou A, Williams P, Downie JA (1999) Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae. J Bacteriol 181:3816–3823PubMedGoogle Scholar
  88. Rosemeyer V, Michiels J, Verreth C, Vanderleyden J (1998) LuxI-and luxR-homologous genes of Rhizobium etli CNPAF512 contribute to synthesis of autoinducer molecules and nodulation of Phaseolus vulgaris. J Bacteriol 180:815–821PubMedGoogle Scholar
  89. Ruby EG, McFall-Ngai MJ (1992) A squid that glows in the night: development of an animal-bacterial mutualism. J Bacteriol 174:4865–4870PubMedGoogle Scholar
  90. Salmond GPC, Bycroft BW, Stewart GSAB, Williams P (1995) The bacterial ‘enigma’: cracking the code of cell-cell communication. Mol Microbiol 16:615–624PubMedCrossRefGoogle Scholar
  91. Showalter R, Martin MO, Silverman MR (1990) Cloning and nucleotide sequence of luxR, a regulatory gene controlling bioluminescence in Vibrio. J Bacteriol 172:2946–2954PubMedGoogle Scholar
  92. Sitnikov DM, Schineller JB, Baldwin TO (1996) Control of cell division in Escherichia coli: regulation of transcription of ftsQA involves both rpoS and sdiA-mediated autoinduction. Proc Natl Acad Sci 93:336–341PubMedCrossRefGoogle Scholar
  93. Sperandio V, Mellies JL, Nguyen W, Shin S, Kaper JB (1999) Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coli. Proc Natl Acad Sci 96:15196–15201PubMedCrossRefGoogle Scholar
  94. Stevens AM, Greenberg EP (1999) Transcriptional activation by luxR. In: Dunny GM, Winans SC (eds) Cell-cell signaling in bacteria. ASM Press, Washington, DC, pp 231–242Google Scholar
  95. Stock JB, Ninfa AJ, Stock AM (1989) Protein phosphorylation and regulation of adaptive responses in bacteria. Microbiol Rev 53:450–490PubMedGoogle Scholar
  96. Surette MG, Bassler BL (1998) Quorum sensing in Escherichia coli and Salmonella typhimurium. Proc Natl Acad Sci 95:7046–7050PubMedCrossRefGoogle Scholar
  97. Surette MG, Miller MB, Bassler BL (1999) Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production. Proc Natl Acad Sci 96:1639–1644PubMedCrossRefGoogle Scholar
  98. Swift S, Winson MK, Chan PF, Bainton NJ, Birdsall M, Reeves PJ, Rees CED, Chhabra SR, Hill PJ, Throup JP, Bycroft BW, Salmond GPC, Williams P, Stewart GSAB (1993) A novel strategy for the isolation of luxI homologues: evidence for the widespread distribution of a luxR:luxI superfamily in enteric bacteria. Mol Microbiol 10:511–520PubMedCrossRefGoogle Scholar
  99. Swift S, Karlyshev AV, Fish L, Durant EL, Winson MK, Chhabra SR, Williams P, Macintyre S, Stewart GSAB (1997) Quorum sensing in Aeromonas hydrophila and Aeromonas salmonicida: identification of the luxRI homologs AhyRI and AsaRI and their cognate n-acylhomoserine lactone signal molecules. J Bacteriol 179:5271–5281PubMedGoogle Scholar
  100. Swift S, Lynch MJ, Fish L, Kirke DF, Tomas JM, Stewart GSAB, Williams P (1999) Quorum sensing-dependent regulation and blockade of exoprotease production in Aeromonas hydrophila. Infect Immun 67:5192–5199PubMedGoogle Scholar
  101. Throup JP, Camara M, Briggs GS, Winson MK, Chhabra SR, Bycroft BW, Williams P, Stewart GSAB (1995) Characterisation of the yenI/yenR locus from Yersinia enterocolitica mediating the synthesis of two n-acylhomoserine lactone signal molecules. Mol Microbiol 17:345–356PubMedCrossRefGoogle Scholar
  102. Tortosa P, Dubnau D (1999) Competence for transformation: a matter of taste. Curr Opin Microbiol 2:588–592PubMedCrossRefGoogle Scholar
  103. Val DL, Cronan JE Jr (1998) In vivo evidence that s-adenosylmethionine and fatty acid synthesis intermediates are the substrates for the luxI family of autoinducer synthases. J Bacteriol 180:2644–2651PubMedGoogle Scholar
  104. Visick KL, McFall-Ngai MJ (2000) An exclusive contract: specificity in the Vibrio fischeri-Euprymna scolopes partnership. J Bacteriol 182:1779–1787PubMedCrossRefGoogle Scholar
  105. Williams P, Bainton NJ, Swift S, Chhabra SR, Winson MK, Stewart GSAB, Salmond GPC, Bycroft BW (1992) Small molecule-mediated density-dependent control of gene expression in prokaryotes: bioluminescence and the biosynthesis of carbapenem antibiotics. FEMS Microbiol Lett 100:161–168Google Scholar
  106. Winans SC, Zhu J, More MI (1999) Cell density-dependent gene expression by Agrobacterium tumefaciens during colonization of crown gall tumors. In: Dunny GM, Winans SC (eds) Cell-cell signaling in bacteria. ASM Press, Washington, DC, pp 117–128Google Scholar
  107. Winson MK, Camara M, Latifi A, Foglino M, Chhabra SR, Daykin M, Bally M, Chapon V, Salmond GPC, Bycroft BW, Lazdunski A, Stewart GSAB, Williams P (1995) Multiple n-acyl-l-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa. Proc Natl Acad Sci 92:9427–9431PubMedCrossRefGoogle Scholar
  108. Withers HL, Nordstrom K (1998) Quorum-sensing acts at initiation of chromosomal replication in Escherichia coli. Proc Natl Acad Sci 95:15694–15699PubMedCrossRefGoogle Scholar
  109. Wood DW, Gong F, Daykin MM, Williams P, Pierson LS III (1997) N-acyl-homoserine lactone-mediated regulation of phenazine gene expression by Pseudomonas aureofaciens 30-84 in the wheat rhizosphere. J Bacteriol 179:7663–7670PubMedGoogle Scholar
  110. Xu D, Yang C, Kaplan HB (1998) Myxococcus xanthus sasN encodes a regulator that prevents developmental gene expression during growth. J Bacteriol 180:6215–6223PubMedGoogle Scholar
  111. Yang C, Kaplan HB (1997) Myxococcus xanthus sasS encodes a sensor histidine kinase required for early developmental gene expression. J Bacteriol 179:7759–7767PubMedGoogle Scholar
  112. Zhang L, Murphy PJ, Kerr A, Tate ME (1993) Agrobacterium conjugation and gene regulation by n-acyl-l-homoserine lactones. Nature 362:446–448PubMedCrossRefGoogle Scholar
  113. Zhu J, Beaber JW, More MI, Fuqua C, Eberhard A, Winans SC (1998) Analogs of the autoinducer 3-oxooctanoyl-homoserine lactone strongly inhibit activity of the TraR protein of Agrobacterium tumefaciens. J Bacteriol 180:5398–5405PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Bonnie L. Bassler
    • 1
  • Melissa B. Miller
    • 2
  1. 1.Department of Molecular BiologyPrinceton UniversityPrincetonUSA
  2. 2.Department of Pathology and Laboratory MedicineUniversity of North Carolina at Chapel HillChapel HillUSA

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