Vascular Aging and Free Radicals

  • Zoltan Ungvari
  • Akos Koller
  • Peter Toth
  • Anna Csiszar
Reference work entry


Understanding common causes of late-life cardiovascular disease, stroke, peripheral artery disease, and vascular cognitive impairment is important as it enables the development of novel approaches to extend the healthspan of the elderly. This overview focuses on cellular mechanisms promoting vascular oxidative stress during aging, including NADPH oxidase activation and mitochondrial ROS production; describes the role of age-related GH/IGF-1 deficiency and dysregulation of Nrf2; and explores the links between mitochondrial oxidative stress, inflammation, endothelial dysfunction, endothelial apoptosis, and development of vascular diseases in the elderly.


Nitric Oxide NADPH Oxidase Peripheral Artery Disease Vascular Cognitive Impairment Mitochondrial Oxidative Stress 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by grants from the American Heart Association (to ZU, AK, PT, and AC), American Federation for Aging Research (to AC), the Oklahoma Center for the Advancement of Science and Technology (to AC and ZU), the NIH (AG031085 to AC, AT006526 to ZU), the Hungarian National Science Research Funds (OTKA K71591), the Hungarian National Development Agency (TÁMOP/SROP-4.2.1/b-10/2/KONV-2010-0012), and the Arkansas Claude Pepper Older Americans Independence Center at University of Arkansas Medical Center (to AC). The authors would like to express their gratitude for the support of the Donald W. Reynolds Foundation, which funds aging research at the University of Oklahoma Health Sciences Center under its Aging and Quality of Life Program.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Zoltan Ungvari
    • 1
    • 2
  • Akos Koller
    • 2
  • Peter Toth
    • 1
  • Anna Csiszar
    • 1
    • 2
  1. 1.Department of Geriatric Medicine, Reynolds Oklahoma Center on AgingUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA
  2. 2.Department of Pathophysiology and Gerontology and Szentágothai János Tudományos és KutatóközpontUniversity of PécsPécsHungary

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