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Systems Biology of Free Radicals and Antioxidants pp 3599–3623Cite as

Free Radical Biology of Eye Diseases

Abstract

In the eye, cells are constantly exposed to the effects of reactive oxygen species (ROS) deriving from either external sources or endogenous metabolism. The production of ROS is balanced by antioxidant defenses, including enzymes that remove ROS (superoxide dismutase, catalase, peroxidase), proteins, low molecular weight peptides and cofactors (glutathione, NADPH, thioredoxin), and lipid- and water-soluble low molecular weight that scavenge reactive oxygen and nitrogen species (α-tocopherol, ascorbic acid and β-carotene). When ROS production overwhelms the cellular antioxidant defenses, cells are under oxidative stress. Oxidative stress/damage has been implicated in the pathogenesis of a number of ocular diseases including cataracts, age-related macular degeneration, glaucoma, etc.

Keywords

  • Cataracts
  • Free radicals
  • Glaucoma
  • Macular degeneration
  • Oxidative stress

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Fig. 159.1
Fig. 159.2
Fig. 159.3
Fig. 159.4

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Authors and Affiliations

  1. Institute of Biochemistry, Medical Faculty Pristina, Anri Dinan Street bb, 38220, Kosovska Mitrovica, Serbia

    Bojana Kisic & Dijana Miric

  2. Clinic for Eye Diseases, Medical Faculty Pristina, Anri Dinan Street bb, 38220, Kosovska Mitrovica, Serbia

    Lepsa Zoric

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  1. Bojana Kisic
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  2. Dijana Miric
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  3. Lepsa Zoric
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Correspondence to Bojana Kisic .

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  1. Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, British Columbia, Canada

    Ismail Laher

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Kisic, B., Miric, D., Zoric, L. (2014). Free Radical Biology of Eye Diseases. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_192

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