Synonyms
Chiral HPLC; Chiral recognition; Chiral separation; Enantiomer separation; Enantioseparation
Definition
If the mirror image of a compound is structurally different from each other just like our right and left hands, the compound is chiral and a pair of enantiomers (optical isomers) exists. The separation of enantiomers has been called “optical resolution” or just “resolution.” More recently, “enantioseparation” and “chiral separation” are also used in the same meaning. Most chemical and physical properties of enantiomers are identical, and therefore, their separation is not easy. To separate enantiomers, we usually have to receive the aid of chiral, optically active compounds or materials. In usual chromatographic resolutions by gas or liquid phase, the chiral materials have been called as the chiral stationary phases (CSPs).
Introduction
In 1848, Louis Pasteur succeeded in the first separation (resolution) of enantiomers by the direct crystallization of a racemic mixture...
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Okamoto, Y., Shen, J. (2015). Optical Resolution Materials. In: Kobayashi, S., Müllen, K. (eds) Encyclopedia of Polymeric Nanomaterials. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29648-2_135
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