Encyclopedia of Pain

2013 Edition
| Editors: Gerald F. Gebhart, Robert F. Schmidt

Retrograde Cellular Changes After Nerve Injury

  • Pablo BrumovskyEmail author
  • Marcelo Villar
  • Tomas Hökfelt
Reference work entry
DOI: https://doi.org/10.1007/978-3-642-28753-4_3823



 Retrograde changes here refer to the alteration in expression of various molecules in the parent dorsal root ganglion (DRG, sensory) or autonomic neurons after any type of lesion of the peripheral axon (branch). This occurs in humans after various types of lesions, for example, surgery, and is mimicked in experimental animal models, mainly in attempts to understand mechanisms underlying  neuropathic pain.


Nerve Injury and Neuropathic Pain

Nerve injury, such as transection of a nerve (axotomy), occurs under a wide variety of circumstances in real life, ranging from a simple accidental cut during cooking to more or less complicated surgical procedures in hospitals, amputation of a limb being the extreme. Early work on experimental animals by Wall, Devor, and colleagues showed that such a...

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This work was supported by the Swedish Research Council, the Marianne and Marcus Wallenberg Foundation, the Knut and Alice Wallenberg Foundation, funds from Karolinska Institutet, the International Association for the Study of Pain, an Unrestricted Bristol-Myers Squibb Neuroscience Grant, CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), and the Austral University. We thank Drs. Zsuzsanna Wiesenfeld-Hallin, Xiao-Jun Xu, and Zhang Xu for valuable support.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Pablo Brumovsky
    • 1
    • 2
    Email author
  • Marcelo Villar
    • 1
  • Tomas Hökfelt
    • 3
  1. 1.Faculty of Biomedical SciencesAustral UniversityBuenos AiresArgentina
  2. 2.Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)Buenos AiresArgentina
  3. 3.Department of NeuroscienceKarolinska InstituteStockholmSweden