Definition
Aseptic inflammatory monoarthritis induced by injections of kaolin and carrageenan into the synovial cavity of one knee joint results in damage to the cartilage, inflammation of the synovia and synovial fluid exudates, as well as pain behavior and neuroplastic changes in the peripheral and central nervous system.
Characteristics
The K/C arthritis is a well-established model of an acute onset monoarthritis resembling osteoarthritis, which is characterized by degeneration of hyaline articular cartilage and subsequent inflammation and pain. The K/C arthritis model has been used in cats (Coggeshall et al. 1983; Schaible and Grubb 1993), monkeys (Dougherty et al. 1992), rats (Neugebauer et al. 1993; Sluka and Westlund 1993), mice (Zhang et al. 2001; Gatta et al. 2012), and guinea pigs (Gomis et al. 2007) to study pain...
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References
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Neugebauer, V. (2013). Arthritis Model, Kaolin-Carrageenan-Induced Arthritis (Knee). In: Gebhart, G.F., Schmidt, R.F. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28753-4_283
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DOI: https://doi.org/10.1007/978-3-642-28753-4_283
Publisher Name: Springer, Berlin, Heidelberg
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