Evaluation of Hypertension in Childhood Diseases

  • Eileen D. Brewer
  • Sarah J. Swartz
Living reference work entry


Evaluation of hypertension in the pediatric age group should be guided by the patient age and severity of hypertension at presentation and whether the hypertension is sustained or transient. Severe hypertension (stage 2) should always be treated promptly, even before definitive evaluation. The most common causes of hypertension differ by age group (Table 1), so after basic screening evaluation, the specific evaluation of hypertension will be dictated by the most likely underlying diagnoses (Fig. 1).


Compute Tomographic Angiography MRAMagnetic Resonance Angiography Renal Artery Stenosis Congenital Adrenal Hyperplasia Turner Syndrome 
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  1. 1.
    National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004;114:555–76.CrossRefGoogle Scholar
  2. 2.
    Bartosh SM, Aronson AJ. Childhood hypertension: an update on etiology, diagnosis and treatment. Pediatr Clin North Am. 1999;46:235–52.PubMedCrossRefGoogle Scholar
  3. 3.
    Anyaegbu EI, Dharnidharka VR. Hypertension in the teenager. Pediatr Clin North Am. 2014;61:131–51.PubMedCentralPubMedCrossRefGoogle Scholar
  4. 4.
    Ellis D, Miyashita Y. Primary hypertension and special aspects of hypertension in older children and adolescents. Adolesc Health Med Ther. 2011;2:45–62.PubMedCentralPubMedCrossRefGoogle Scholar
  5. 5.
    Ingelfinger JR. The child or adolescent with elevated blood pressure. N Engl J Med. 2014;370:2316–25.PubMedCrossRefGoogle Scholar
  6. 6.
    Flynn JT. The changing face of pediatric hypertension in the era of the childhood obesity epidemic. Pediatr Nephrol. 2013;28:1059–66.PubMedCrossRefGoogle Scholar
  7. 7.
    Rosner B, Cook NR, Daniels S, et al. Childhood blood pressure trends and risk factors for high blood pressure. The NHANES Experience 1988–2008. Hypertension. 2013;62:247–54.PubMedCentralPubMedCrossRefGoogle Scholar
  8. 8.
    Members of the 1996 Working Group were Falkner B, Daniels SR, Loggie JMH, Horan MJ, Prineas RJ, Rosner B, Sinaiko AR. Update on the 1987 Task force report on high blood pressure in children and adolescents: a working group report from the national high blood pressure education program. Pediatrics. 1996;98:649–58.Google Scholar
  9. 9.
    Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. JAMA. 2003;289:2560–72.PubMedCrossRefGoogle Scholar
  10. 10.
    James PA, Oparil S, Carter BL, et al. 2014 Evidence-based guideline for the management of high blood pressure in adults. Report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014;311:507–20.Google Scholar
  11. 11.
    Kent AL, Keeskes Z, Shadbolt B, Falk M. Blood pressure in the first year of life in healthy infants born at term. Pediatr Nephrol. 2007;22:1743–9.PubMedCrossRefGoogle Scholar
  12. 12.
    Dione JM, Abitbol CL, Flynn JT. Hypertension in infancy: diagnosis, management and outcome. Pediatr Nephrol. 2012;27:17–32.CrossRefGoogle Scholar
  13. 13.
    Members of the 1987 Task Force were Horan MJ, Falkner B, Kimm SYS, Loggie JMH, Prineas RJ, Rosner B, Hutchinson J, Lauer R, Mueller S, Riopel DA, Sinaiko A, Weidman WH. Report of the second task force on blood pressure control in children – 1987. Pediatrics. 1987;79:1–25.Google Scholar
  14. 14.
    Park MK, Menard SW. Schoolfield J. Oscillometric blood pressure standards for children. Pediatr Cardiol. 2005;26:601–7.PubMedCrossRefGoogle Scholar
  15. 15.
    Flynn JT, Pierce CB, Miller ER, et al. Reliability of resting blood pressure measurement and classifications using an oscillometric device in children with chronic kidney disease. J Pediatr. 2012;160:434–40.PubMedCentralPubMedCrossRefGoogle Scholar
  16. 16.
    Barba G, Buck C, Bammann K, et al. Blood pressure reference values for European non-overweight school children: the IDEFICS study. Int J Obes (Lond). 2014;38:S48–56.CrossRefGoogle Scholar
  17. 17.
    Wong S-N, Tz Sung RY, Leung LC. Validation of three oscillometric blood pressure devices against auscultatory mercury sphygmomanometer in children. Blood Press Monit. 2006;11:281–91.PubMedCrossRefGoogle Scholar
  18. 18.
    Flynn JT, Daniels SR, Hayman LL, et al. Update: ambulatory blood pressure monitoring in children and adolescents. A scientific statement from the American Heart Association. Hypertension. 2014;63:1116–35.PubMedCentralPubMedCrossRefGoogle Scholar
  19. 19.
    Chaudhuri A. Pediatric ambulatory blood pressure monitoring: diagnosis of hypertension. Pediatr Nephrol. 2013;28:995–9.PubMedCrossRefGoogle Scholar
  20. 20.
    Swartz SJ, Srivaths P, Croix B, et al. Cost-effectiveness of ambulatory blood pressure monitoring in the initial evaluation of hypertension in children. Pediatrics. 2008;122:1177–81.PubMedCrossRefGoogle Scholar
  21. 21.
    Davis ML, Ferguson MA, Zachariah JP. Clinical predictors and impact of ambulatory blood pressure monitoring in pediatric hypertension referrals. J Am Soc Hypertens. 2014;8:660–7.PubMedCrossRefGoogle Scholar
  22. 22.
    Sanders BP, Portman RJ, Ramey RA, et al. Hypertension during reduction of long-term steroid therapy in young subjects with asthma. J Allergy Clin Immunol. 1992;89:816–21.PubMedCrossRefGoogle Scholar
  23. 23.
    Ferdinand KC. Substance abuse and hypertension. J Clin Hypertens. 2000;2:37–40.Google Scholar
  24. 24.
    Klein-Schwartz W, McGrath J. Poison centers’ experience with methylphenidate abuse in preteens and adolescents. J Am Acad Child Adolesc Psychiatry. 2003;42:288–94.PubMedCrossRefGoogle Scholar
  25. 25.
    Savoca MR, Evans CD, Wilson ME, et al. The association of caffeinated beverages with blood pressure in adolescents. Arch Pediatr Adolesc Med. 2004;158:473–7.PubMedCrossRefGoogle Scholar
  26. 26.
    Law CM, Sheill AW, Newsome CA, et al. Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age. Circulation. 2002;105:1088–92.PubMedCrossRefGoogle Scholar
  27. 27.
    Ponzio C, Palomino Z, Puccini RF, et al. Does low birth weight affect the presence of cardiometabolic risk factors in overweight and obese children ? Eur J Pediatr. 2013;172:1687–92.PubMedCrossRefGoogle Scholar
  28. 28.
    Sipola-Leppanen M, Vaarasmaki M, Tikanmaki M, et al. Cardiovascular risk factors in adolescents born premature. Pediatrics. 2014;134:e1072–81.PubMedCrossRefGoogle Scholar
  29. 29.
    Vora CK, Mansoor GA. Herbs and alternative therapies: relevance to hypertension and cardiovascular diseases. Curr Hypertens Rep. 2005;7:275–80.PubMedCrossRefGoogle Scholar
  30. 30.
    Jalili J, Askeroglu U, Alleyne B, Guyuron B. Herbal products that may contribute to hypertension. Plast Reconstr Surg. 2013;131:168–73.PubMedCrossRefGoogle Scholar
  31. 31.
    Williams KM, Shah AN, Morrison D, Sinha MD. Hypertensive retinopathy in severely hypertensive children: demographic, clinical, and ophthalmoscopic findings from a 30-year British cohort. J Pediatr Ophthalmol Strabismus. 2013;50:222–8.PubMedCrossRefGoogle Scholar
  32. 32.
    Siegler RL, Brewer ED, Corneli HM, et al. Hypertension first seen as facial paralysis. Pediatrics. 1991;87:387–9.PubMedGoogle Scholar
  33. 33.
    Lewis VE, Peat DS, Tizard EJ. Hypertension and facial palsy in middle aortic syndrome. Arch Dis Child. 2001;85:240–1.PubMedCentralPubMedCrossRefGoogle Scholar
  34. 34.
    Daniels SR, Loggie JM, McEnery PT, et al. Clinical spectrum of intrinsic renovascular hypertension in children. Pediatrics. 1987;80:698–704.PubMedGoogle Scholar
  35. 35.
    Schwartz GJ. Height: the missing link in estimating glomerular filtration rate in children and adolescents. Nephrol Dial Transplant. 2014;29:944–7.PubMedCentralPubMedCrossRefGoogle Scholar
  36. 36.
    Carman TL, Olin JW, Czum J. Noninvasive imaging of the renal arteries. Urol Clin North Am. 2001;28:815–26.PubMedCrossRefGoogle Scholar
  37. 37.
    Chhadia S, Cohn RA, Vural G, Donaldson JS. Renal Doppler evaluation in the child with hypertension: a reasonable screening discriminator? Pediatr Radiol. 2013;43:1549–56.PubMedCrossRefGoogle Scholar
  38. 38.
    Castelli PK, Dillman JR, Kershaw DB, et al. Renal sonography with Doppler for detecting suspected pediatric renin-mediated hypertension – is it adequate? Pediatr Radiol. 2014;44:42–9.PubMedCrossRefGoogle Scholar
  39. 39.
    Yanik M, Feig DI. Serum urate: a biomarker or treatment target in pediatric hypertension ? Curr Opin Cardiol. 2013;28:433–8.PubMedGoogle Scholar
  40. 40.
    Viazzi F, Antolini L, Giussani M, et al. Serum uric acid and blood pressure in children at cardiovascular risk. Pediatrics. 2013;132:e93–9.PubMedCrossRefGoogle Scholar
  41. 41.
    Deal JE, Snell ME, Barratt TM, et al. Renovascular disease in childhood. J Pediatr. 1992;121:378–84.PubMedCrossRefGoogle Scholar
  42. 42.
    Tullus K, Brennan E, Hamilton G, et al. Renovascular hypertension in children. Lancet. 2008;371:1453–63.PubMedCrossRefGoogle Scholar
  43. 43.
    Lagomarsino E, Orellana P, Munoz J, et al. Captopril scintigraphy in the study of arterial hypertension in pediatrics. Pediatr Nephrol. 2004;19:66–70.PubMedCrossRefGoogle Scholar
  44. 44.
    Reusz G, Kis E, Cseprekal O, et al. Captopril-enhanced renal scintigraphy in the diagnosis of pediatric hypertension. Pediatr Nephrol. 2010;25:185–9.PubMedCrossRefGoogle Scholar
  45. 45.
    Adelman RD. Long-term follow-up of neonatal renovascular hypertension. Pediatr Nephrol. 1987;1:36–41.CrossRefGoogle Scholar
  46. 46.
    Adelman RD, Morrell RE. Coarctation of the abdominal aorta and renal artery stenosis related to an umbilical artery catheter placement in a neonate. Pediatrics. 2000;106:E36.PubMedCrossRefGoogle Scholar
  47. 47.
    Marks SK, Tullus K. Update on imaging for suspected renovascular hypertension in children and adolescents. Curr Hypertens Rep. 2012;14:591–5.PubMedCrossRefGoogle Scholar
  48. 48.
    Srinivasan A, Krishnamurthy G, Fontalvo-Herazo L, et al. Angioplasty for renal artery stenosis in pediatric patients: an 11-year retrospective experience. J Vasc Interv Radiol. 2010;21:1672–80.PubMedCrossRefGoogle Scholar
  49. 49.
    Booth C, Preston R, Clark G, et al. Management of renal vascular disease in neurofibromatosis type I and the role of percutaneous transluminal angioplasty. Nephrol Dial Transplant. 2002;17:1235–40.PubMedCrossRefGoogle Scholar
  50. 50.
    Fossali E, Signorini E, Intermite RC, et al. Renovascular disease and hypertension in children with neurofibromatosis. Pediatr Nephrol. 2000;14:806–10.PubMedCrossRefGoogle Scholar
  51. 51.
    Shroff R, Roebuck DJ, Gordon I, et al. Angioplasty for renovascular hypertension in children: 20-year experience. Pediatrics. 2006;118:268–75.PubMedCrossRefGoogle Scholar
  52. 52.
    Huang Y, Duncan AA, McKusick MA, et al. Renal artery intervention in pediatric and adolescent patients: a 20-year experience. Vasc Endovascular Surg. 2008;41:490–9.CrossRefGoogle Scholar
  53. 53.
    Colyer JH, Ratnayaka K, Slack MC, Kanter JP. Renal artery stenosis in children: therapeutic percutaneous balloon and stent angioplasty. Pediatr Nephrol. 2014;29:1067–74.PubMedCrossRefGoogle Scholar
  54. 54.
    Liang CD, Wu CJ, Fang CY, et al. Endovascular stent placement for management of total renal artery occlusion in a child. J Invasive Cardiol. 2002;14:32–5.PubMedGoogle Scholar
  55. 55.
    Glockner JF, Vrtiska TJ. Renal MR and CT angiography: current concepts. Abdom Imaging. 2007;32:407–20.PubMedCrossRefGoogle Scholar
  56. 56.
    Castelli PK, Dillman JR, Smith EA, et al. Imaging of renin-mediated hypertension in children. Am J Roentgenol. 2013;200:W661–72.CrossRefGoogle Scholar
  57. 57.
    Rountas C, Vlychou M, Vassiou K, et al. Imaging modalities for renal artery stenosis in suspected renovascular hypertension: prospective intraindividual comparison of color Doppler US, CT angiography, GD-enhanced MR angiography, and digital subtraction angiography. Ren Fail. 2007;29:295–302.PubMedCrossRefGoogle Scholar
  58. 58.
    Kurian J, Epelman M, Darge K, et al. The role of CT angiography in the evaluation of pediatric renovascular hypertension. Pediatr Radiol. 2013;43:490–501.PubMedCrossRefGoogle Scholar
  59. 59.
    Perazella MA, Rodby RA. Gadolinium use in patients with kidney disease: a cause for concern. Semin Dial. 2007;20:179–85.PubMedCrossRefGoogle Scholar
  60. 60.
    Shellock FG, Spinazzi A. MRI safety update 2008: Part I, MRI contrast agents and nephrogenic systemic fibrosis. AJR Am J Roentgenol. 2008;191:1129–39.PubMedCrossRefGoogle Scholar
  61. 61.
    Ledneva E, Karie S, Launay-Vacher V, et al. Renal safety of gadolinium-based contrast media in patients with chronic renal insufficiency. Radiology. 2009;250:618–28.PubMedCrossRefGoogle Scholar
  62. 62.
    Mustafa AE, Bloom DA, Valentini RP, et al. MR angiography in the evaluation of a renovascular cause of neonatal hypertension. Pediatr Radiol. 2006;36:158–61.PubMedCrossRefGoogle Scholar
  63. 63.
    Goonasekera CDA, Shah V, Wade AM, et al. The usefulness of renal vein renin studies in hypertensive children: a 25-year experience. Pediatr Nephrol. 2002;17:943–9.PubMedCrossRefGoogle Scholar
  64. 64.
    Martinez-Maldonado M. Pathophysiology of renovascular hypertension. Hypertension. 1991;17:707–19.PubMedCrossRefGoogle Scholar
  65. 65.
    Pickering TG, Sos TA, James GD. Comparison of renal vein renin activity in hypertensive patients with stenosis of one or both renal arteries. J Hypertens. 1985;3 Suppl 3:S291–3.Google Scholar
  66. 66.
    Fry WJ, Ernst BC, Stanley JC, et al. Renovascular hypertension in the pediatric patient. Arch Surg. 1973;107:692–8.PubMedCrossRefGoogle Scholar
  67. 67.
    Makker SP, Moorthy B. Fibromuscular dysplasia of renal arteries. An important cause of renovascular hypertension in children. J Pediatr. 1979;95:940–5.PubMedCrossRefGoogle Scholar
  68. 68.
    Plouin P-F, Perdu J, Batide-Alanore A, et al. Fibromuscular dysplasia. Orphanet J Rare Dis. 2007;2:28–35.PubMedCentralPubMedCrossRefGoogle Scholar
  69. 69.
    Han M, Criado E. Renal artery stenosis and aneurysms associated with neurofibromatosis. J Vasc Surg. 2005;41:539–43.PubMedCrossRefGoogle Scholar
  70. 70.
    Ingelfinger JR, Newburger JW. Spectrum of renal anomalies in patients with Williams syndrome. J Pediatr. 1991;119:771–3.PubMedCrossRefGoogle Scholar
  71. 71.
    Rose C, Wessel A, Pankau R, et al. Anomalies of the abdominal aorta in Williams-Beuren syndrome – another cause of arterial hypertension. Eur J Pediatr. 2001;160:655–8.PubMedCrossRefGoogle Scholar
  72. 72.
    Bouchireb K, Boyer O, Bonnet D, et al. Clinical features and management of arterial hypertension in children with Williams-Beuren syndrome. Nephrol Dial Transplant. 2010;25:434–8.PubMedCrossRefGoogle Scholar
  73. 73.
    Gao J, Ng A, Shih G, et al. Intrarenal color duplex ultrasonography: a window to vascular complications of renal transplants. J Ultrasound Med. 2007;26:1403–18.PubMedGoogle Scholar
  74. 74.
    Mutze S, Turk I, Schonberger B, et al. Colour-coded duplex sonography in the diagnostic assessment of vascular complications after kidney transplantation in children. Pediatr Radiol. 1997;27:898–902.PubMedCrossRefGoogle Scholar
  75. 75.
    Heemann U, Lutz J. Pathophysiology and treatment options of chronic renal allograft damage. Nephrol Dial Transplant. 2013;28:2438–46.PubMedCrossRefGoogle Scholar
  76. 76.
    Steinbrecher HA, Malone PS. Wilms tumour and hypertension: incidence and outcome. Br J Urol. 1995;76:241–3.PubMedCrossRefGoogle Scholar
  77. 77.
    Londe S. Causes of hypertension in the young. Pediatr Clin North Am. 1978;25:55–8.PubMedGoogle Scholar
  78. 78.
    Alpert BS, Bain HH, Balfe JW. Role of the renin-angiotensin-aldosterone system in hypertensive children with coarctation of the aorta. Am J Cardiol. 1979;43:828–31.PubMedCrossRefGoogle Scholar
  79. 79.
    Soler R, Rodriquez E, Requejo I, et al. Magnetic resonance imaging of congenital abnormalities of the thoracic aorta. Eur Radiol. 1998;8:540–6.PubMedCrossRefGoogle Scholar
  80. 80.
    Lim DS, Ralston MA. Echocardiographic indices of Doppler flow patterns compared with MRI or angiographic measurements to detect significant coarctation of the aorta. Echocardiography. 2002;19:55–60.PubMedCrossRefGoogle Scholar
  81. 81.
    de Roos A, Roest AAW. Evaluation of congenital heart disease by magnetic resonance imaging. Eur Radiol. 2000;10:2–6.PubMedCrossRefGoogle Scholar
  82. 82.
    Godart F, Labrot G, Devos P, et al. Coarctation of the aorta: comparison of aortic dimensions between conventional MR imaging, 3D MR angiography, and conventional angiography. Eur Radiol. 2002;12:2034–9.PubMedCrossRefGoogle Scholar
  83. 83.
    Rupprecht T, Nitz W, Wagner M, et al. Determination of the pressure gradient in children with coarctation of the aorta by low-field magnetic resonance imaging. Pediatr Cardiol. 2002;23:127–31.PubMedCrossRefGoogle Scholar
  84. 84.
    Hu X-H, Huang G-Y, Pa M, et al. Multidetector CT angiography and 3D reconstruction in young children with coarctation of the aorta. Pediatr Cardiol. 2008;29:726–31.PubMedCrossRefGoogle Scholar
  85. 85.
    Sen PK, Kinare SG, Engineer SD, et al. The middle aortic syndrome. Br Heart J. 1963;25:610–8.PubMedCentralPubMedCrossRefGoogle Scholar
  86. 86.
    Sethna CB, Kaplan BS, Cahill AM, et al. Idiopathic mid-aortic syndrome in children. Pediatr Nephrol. 2008;23:1135–42.PubMedCrossRefGoogle Scholar
  87. 87.
    Criado E, Izquierdo L, Lujan S, et al. Abdominal aortic coarctation, renovascular hypertension, and neurofibromatosis. Ann Vasc Surg. 2002;16:363–7.PubMedCrossRefGoogle Scholar
  88. 88.
    Radford DJ, Pohlner PG. The middle aortic syndrome: an important feature of Williams’ syndrome. Cardiol Young. 2000;10:597–602.PubMedCrossRefGoogle Scholar
  89. 89.
    Eronen M, Peippo M, Hiippala A, et al. Cardiovascular manifestations in 75 patients with Williams syndrome. J Med Genet. 2002;39:554–8.PubMedCentralPubMedCrossRefGoogle Scholar
  90. 90.
    Tummulo A, Marks SD, Stadermann M, et al. Mid-aortic syndrome: long-term outcome of 36 children. Pediatr Nephrol. 2009;24:2225–32.CrossRefGoogle Scholar
  91. 91.
    Sybert VP. Cardiovascular malformations and complications in Turner syndrome. Pediatrics. 1998;101:E11.PubMedCrossRefGoogle Scholar
  92. 92.
    Landin-Wilhelmsen K, Bryman I, Wilhelmsen L. Cardiac malformations and hypertension, but not metabolic risk factors, are common in Turner syndrome. J Clin Endocrinol Metab. 2001;86:4166–70.PubMedCrossRefGoogle Scholar
  93. 93.
    Nathwani NC, Unwin R, Brook CG, et al. Blood pressure and Turner syndrome. Clin Endocrinol. 2000;52:363–70.CrossRefGoogle Scholar
  94. 94.
    Nathwani NC, Unwin R, Brook CG, et al. The influence of renal and cardiovascular abnormalities on blood pressure in Turner syndrome. Clin Endocrinol. 2000;52:371–7.CrossRefGoogle Scholar
  95. 95.
    Dillon MJ. Investigation and management of hypertension in children. A personal perspective. Pediatr Nephrol. 1987;1:59–68.PubMedCrossRefGoogle Scholar
  96. 96.
    Arar MY, Hogg RJ, Arant BS, et al. Etiology of sustained hypertension in children in the southwestern United States. Pediatr Nephrol. 1994;8:186–9.PubMedCrossRefGoogle Scholar
  97. 97.
    Dillon MJ, Goonasekera CDA. Reflux nephropathy. J Am Soc Nephrol. 1998;9:2377–83.PubMedGoogle Scholar
  98. 98.
    Simoes e Silva AC, Silva JP, Diniz JS, et al. Risk of hypertension in primary vesicoureteral reflux. Pediatr Nephrol. 2007;22:459–62.PubMedCrossRefGoogle Scholar
  99. 99.
    Rotin D. Role of the UPS in Liddle syndrome. BMC Biochem. 2008;9 Suppl 1:S5–11.PubMedCentralPubMedCrossRefGoogle Scholar
  100. 100.
    Assadi FK, Kimura RE, Subramanian U, et al. Liddle syndrome in a newborn infant. Pediatr Nephrol. 2002;17:609–11.PubMedCrossRefGoogle Scholar
  101. 101.
    Warnock DG. Liddle syndrome: genetics and mechanisms of Na + channel defects. Am J Med Sci. 2001;322:302–7.PubMedCrossRefGoogle Scholar
  102. 102.
    Gordon I. Indications for 99mtechnetium dimercaptosuccinic acid scan in children. J Urol. 1987;137:464–7.PubMedGoogle Scholar
  103. 103.
    Stokland E, Hellstrom M, Jakobsson B, et al. Imaging of renal scarring. Acta Paediatr Suppl. 1999;88:13–21.PubMedCrossRefGoogle Scholar
  104. 104.
    Peters AM, Jones DH, Evans K, et al. Two routes for 99mTc-DMSA uptake into the renal cortical tubular cell. Eur J Nucl Med. 1988;14:555–61.PubMedCrossRefGoogle Scholar
  105. 105.
    Ask-Upmark E, Fagerberg S. Renal arteriography in arterial hypertension. Acta Med Scand. 1965;178:577–82.PubMedCrossRefGoogle Scholar
  106. 106.
    Arant BS, Sotelo-Avila C, Bernstein J. Segmental “hypoplasia” of the kidney (Ask-Upmark). J Pediatr. 1979;95:931–9.PubMedCrossRefGoogle Scholar
  107. 107.
    Tash JA, Stock JA, Hanna MK. The role of partial nephrectomy in the treatment of pediatric renal hypertension. J Urol. 2003;169:625–8.PubMedCrossRefGoogle Scholar
  108. 108.
    Rodd CJ, Sockalosky JJ. Endocrine causes of hypertension in children. Pediatr Clin North Am. 1993;40:149–64.PubMedGoogle Scholar
  109. 109.
    Havekes B, Romijn JA, Eisenhofer G, et al. Update on pediatric pheochromocytoma. Pediatr Nephrol. 2009;24:943–50.PubMedCrossRefGoogle Scholar
  110. 110.
    Lenders JWM, Duh Q-Y, Eisenhofer G, et al. Pheochromocytoma and paraganglioma: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2014;99:1915–41.PubMedCrossRefGoogle Scholar
  111. 111.
    Reddy VS, O’Neill JA, Holcomb GW, et al. Twenty-five year surgical experience with pheochromocytoma in children. Am Surg. 2000;66:1085–91.PubMedGoogle Scholar
  112. 112.
    Eisenhofer G, Lenders JW, Linehan WM, et al. Plasma normetanephrine and metanephrine for detecting pheochromocytoma in von Hippel-Lindau disease and multiple endocrine neoplasia type 2. N Engl J Med. 1999;340:1872–9.PubMedCrossRefGoogle Scholar
  113. 113.
    Weise M, Merke DP, Pacak K, et al. Utility of plasma free metanephrines for detecting childhood pheochromocytoma. J Clin Endocrinol Metab. 2002;87:1955–60.PubMedCrossRefGoogle Scholar
  114. 114.
    Leung A, Shapiro B, Hattner R, et al. Specificity of radioiodinated MIBG for neural crest tumors in childhood. J Nucl Med. 1997;38:1351–7.Google Scholar
  115. 115.
    Shulkin BL, Shapiro B. Current concepts on the diagnostic use of MIBG in children. J Nucl Med. 1998;39:679–88.PubMedGoogle Scholar
  116. 116.
    Olivier P, Colarinha P, Fettich J, et al. Guidelines for radioiodinated MIBG scintigraphy in children. Eur J Nucl Med Mol Imaging. 2003;30:BP45–50.CrossRefGoogle Scholar
  117. 117.
    Abbi RK, McVicar M, Teichberg S, et al. Pathologic characterization of a renin-secreting juxtaglomerular cell tumor in a child and review of the pediatric literature. Pediatr Pathol. 1993;13:443–51.PubMedCrossRefGoogle Scholar
  118. 118.
    Haab F, Duclos J, Guyenne T, et al. Renin secreting tumors: diagnosis, conservative surgical approach and long-term results. J Urol. 1995;153:1781–4.PubMedCrossRefGoogle Scholar
  119. 119.
    Spahr J, Demers LM, Shochat SJ. Renin producing Wilms’ tumor. J Pediatr Surg. 1981;16:32–4.PubMedCrossRefGoogle Scholar
  120. 120.
    Dernellis J, Panaretou M. Effects of thyroid replacement therapy on arterial blood pressure in patients with hypertension and hypothyroidism. Am Heart J. 2002;143:718–24.PubMedCrossRefGoogle Scholar
  121. 121.
    Stratakis CA. Cushing syndrome in pediatrics. Endocrinol Metab Clin N Am. 2012;41:793–803.CrossRefGoogle Scholar
  122. 122.
    Vehaskari VM. Heritable forms of hypertension. Pediatr Nephrol. 2009;24:1929–37.PubMedCentralPubMedCrossRefGoogle Scholar
  123. 123.
    Cerame BI, New MI. Hormonal hypertension in children: 11beta-hydroxylase deficiency and apparent mineralocorticoid excess. J Pediatr Endocrinol Metab. 2000;13:1537–47.PubMedCrossRefGoogle Scholar
  124. 124.
    Dacou-Voutetakis C, Maniati-Christidi M, Dracopoulou-Vabouli M. Genetic aspects of congenital adrenal hyperplasia. J Pediatr Endocrinol Metab. 2001;14 Suppl 5:1303–8.PubMedGoogle Scholar
  125. 125.
    White PC, Curnow KM, Pascoe L. Disorders of steroid 11 beta-hydroxylase isoenzymes. Endocr Rev. 1994;15:421–38.PubMedGoogle Scholar
  126. 126.
    Winter JS, Couch RM, Muller J, et al. Combined 17-hydroxylase and 17,20-desmolase deficiencies. Evidence for synthesis of a defective cytochrome P450c17. J Clin Endocrinol Metab. 1989;68:309–16.PubMedCrossRefGoogle Scholar
  127. 127.
    Winter JS. Clinical, biochemical and molecular aspects of 17-hydroxylase deficiency. Endocr Res. 1991;17:53–62.PubMedCrossRefGoogle Scholar
  128. 128.
    Rebaud P, Berthier JC, Hartemann E, et al. Intracranial pressure in childhood central nervous system infections. Intensive Care Med. 1988;14:522–5.PubMedCrossRefGoogle Scholar
  129. 129.
    Proulx F, Lacroix J, Farrell CA, et al. Convulsions and hypertension in children: differentiating cause from effect. Crit Care Med. 1993;21:1541–6.PubMedCrossRefGoogle Scholar
  130. 130.
    Axelrod FB. Familial dysautonomia: a 47-year perspective. How technology confirms clinical acumen. J Pediatr. 1998;132:S2–5.PubMedCrossRefGoogle Scholar
  131. 131.
    Axelrod FB, Goldberg JD, Ye X, et al. Survival in familial dysautonomia: impact of early intervention. J Pediatr. 2002;141:518–23.PubMedCrossRefGoogle Scholar
  132. 132.
    Fernhoff PM. No pains, many gains. J Pediatr. 2002;141:470–1.PubMedCrossRefGoogle Scholar
  133. 133.
    Davis S. Pregnancy in adolescents. Pediatr Clin North Am. 1989;36:665–80.PubMedGoogle Scholar
  134. 134.
    Murdock NM. Teenage pregnancy. J Natl Med Assoc. 1998;90:135–6.PubMedCentralPubMedGoogle Scholar
  135. 135.
    Gortzak-Uzan L, Hallak M, Press F, et al. Teenage pregnancy: risk factor for adverse perinatal outcome. J Matern Fetal Med. 2001;10:393–7.PubMedCrossRefGoogle Scholar
  136. 136.
    Tabacova SA, Kimmel CA. Enalapril: pharmacokinetic/dynamic inferences for comparative developmental toxicity. A review. Reprod Toxicol. 2001;15:467–78.PubMedCrossRefGoogle Scholar
  137. 137.
    Sedman AB, Kershaw DB, Bunchman TE. Recognition and management of angiotensin converting enzyme inhibitor fetopathy. Pediatr Nephrol. 1999;9:382–5.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Pediatrics, Renal SectionBaylor College of Medicine and Texas Children’s HospitalHoustonUSA

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