Pathogenesis of Acute Kidney Injury

  • David P. Basile
  • Rajasree Sreedharan
  • Scott K. Van Why
Living reference work entry


The sudden loss of renal function that may result from inadequate renal perfusion, arterial or venous obstruction, renal cell injury, or acute obstruction to urine flow historically has been termed acute renal failure (ARF). Several years ago the term acute kidney injury (AKI) was proposed to replace the term ARF [1]. Usage of “AKI” is now widespread. Unfortunately it is often used imprecisely, defeating the purpose of the change in nomenclature.


Nitric Oxide Chronic Kidney Disease Glomerular Filtration Rate Acute Kidney Injury Renal Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • David P. Basile
    • 1
  • Rajasree Sreedharan
    • 2
  • Scott K. Van Why
    • 2
  1. 1.Indiana University School of MedicineIndianapolisUSA
  2. 2.Medical College of WisconsinMilwaukeeUSA

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