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Clinical Evaluation of the Child with Suspected Renal Disease

  • Mohan A. Shenoy
  • Nicholas J. A. Webb
Living reference work entry

Abstract

Renal disease in children may present with overt symptoms such as hematuria or oliguria. However, on many occasions, symptoms can be mild or nonspecific. Increasingly many of the congenital anomalies of the renal tract are detected by antenatal ultrasonography. A number of children are referred following detection of abnormality during routine assessment or following screening. A detailed history which includes antenatal, family, and medication history is an essential aspect of evaluation of every child with renal disease. A child with renal disease should have a thorough clinical examination including assessment of growth, nutrition, and hydration. Awareness of genetic and multisystem diseases which involve the kidneys is important.

Keywords

Infective Endocarditis Hemolytic Uremic Syndrome Autosomal Dominant Polycystic Kidney Disease Polycystic Kidney Disease Posterior Urethral Valve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Garrett WJ, Grunwald G, Robinson DE. Prenatal diagnosis of fetal polycystic kidney by ultrasound. Aust NZ J Obst Gynaecol. 1970;10:7–9.CrossRefGoogle Scholar
  2. 2.
    De Bruyn R, Marks SD. Postnatal investigation of fetal renal disease. Semin Fetal Neonatal Med. 2008;13:133–41.PubMedCrossRefGoogle Scholar
  3. 3.
    Helin I, Persson PH. Prenatal diagnosis of urinary tract abnormalities by ultrasound. Pediatrics. 1986;78(5):879–83.PubMedGoogle Scholar
  4. 4.
    Livera LN, Brookfield DS, Egginton JA, et al. Antenatal ultrasonography to detect fetal renal abnormalities: a prospective screening programme. BMJ. 1989;298(6685):1421–3.PubMedCentralPubMedCrossRefGoogle Scholar
  5. 5.
    Smith NC, Hau C. A six year study of the antenatal detection of fetal abnormality in six Scottish health boards. Br J Obstet Gynaecol. 1999;106:206–12.PubMedCrossRefGoogle Scholar
  6. 6.
    Morris RK, Malin GL, Quinlan-Jones E, et al. Percutaneous vesicoamniotic shunting versus conservative management for fetal lower urinary tract obstruction (PLUTO): a randomised trial. Lancet. 2013;382(9903):1496–506.PubMedCentralPubMedCrossRefGoogle Scholar
  7. 7.
    DeCramer S, Parant O, Beaufils S, et al. Anomalies of the TCF2 gene are the main cause of fetal bilateral hyperechogenic kidneys. J Am Soc Nephrol. 2007;18(3):923–33.PubMedCrossRefGoogle Scholar
  8. 8.
    Meadow R. Munchausen syndrome by proxy. Arch Dis Child. 1982;57:92–8.PubMedCentralPubMedCrossRefGoogle Scholar
  9. 9.
    McGee H. On food and cooking: the science and lore of the kitchen. New York: Simon and Schuster; 1997. p. 194.Google Scholar
  10. 10.
    White RH. Occurrence of S-methyl thioesters in urine of humans after they have eaten asparagus. Science. 1975;189:810–1.PubMedCrossRefGoogle Scholar
  11. 11.
    Waring RH, Mitchell SC, Fenwick GR. The chemical nature of the urinary odour produced by man after asparagus ingestion. Xenobiotica. 1987;17:1363–71.PubMedCrossRefGoogle Scholar
  12. 12.
    Sherry SN, Kramer I. The time of passage of the first urine by the newborn infant. J Pediatr. 1955;46:158.PubMedCrossRefGoogle Scholar
  13. 13.
    Muellner S. Development of urinary control in children. JAMA. 1960;172:1256–61.CrossRefGoogle Scholar
  14. 14.
    Forsythe WI, Redmond A. Enuresis and spontaneous cure rate. A study of 1129 enuretics. Arch Dis Child. 1974;49(4):259–63.PubMedCentralPubMedCrossRefGoogle Scholar
  15. 15.
    Kitagawa T. Lessons learned from the Japanese nephritis screening study. Pediat Nephrol. 1988;2:256–63.PubMedCrossRefGoogle Scholar
  16. 16.
    National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114(2 Suppl 4th Report):555–76.Google Scholar
  17. 17.
    Sinha MD, Reid CJ. Evaluation of blood pressure in children. Curr Opin Nephrol Hypertens. 2007;16:577–84.PubMedCrossRefGoogle Scholar
  18. 18.
    Brady TM, Redwine KM, Flynn JT. Screening blood pressure measurement in children: are we saving lives? Pediatr Nephrol. 2014;29:947–50.PubMedCrossRefGoogle Scholar
  19. 19.
    Jakobbson B, Esbjorner E, Hansson S. Minimum incidence and diagnostic rate of first urinary tract infection. Pediatrics. 1999;104:222–6.CrossRefGoogle Scholar
  20. 20.
    Coulthard MG, Lambert H, Keir M. Occurrence of renal scars in children after their first referral for urinary tract infection. BMJ. 1997;315:918–9.PubMedCentralPubMedCrossRefGoogle Scholar
  21. 21.
    Cooper WO, Hernandez-Diaz S, Arbogast PG, et al. Major congenital malformations after first-trimester exposure to ACE inhibitors. N Engl J Med. 2006;354(23):2443–51.PubMedCrossRefGoogle Scholar
  22. 22.
    Rasmussen SA, Chu SY, Kim SY, et al. Maternal obesity and risk of neural tube defects: a metaanalysis. Am J Obstet Gynecol. 2008;198(6):611–9.PubMedCrossRefGoogle Scholar
  23. 23.
    Singh HP, Hurley RM, Myers TF. Neonatal hypertension: incidence and risk factors. Am J Hypertens. 1992;5:51–5.PubMedGoogle Scholar
  24. 24.
    Thummala MR, Raju TN, Langenberg P. Isolated single umbilical artery anomaly and the risk for congenital malformations: a meta-analysis. J Pediatr Surg. 1998;33:580–5.PubMedCrossRefGoogle Scholar
  25. 25.
    Darr A, Modell B. The frequency of consanguineous marriage among British Pakistanis. J Med Genet. 1988;25:186–90.PubMedCentralPubMedCrossRefGoogle Scholar
  26. 26.
    Moghal NE, Milford DV, Hulton SA, Taylor CM. The prevalence and treatment of end stage renal disease in an Asian child population. Nephrol Dial Transpl. 1997;12(12):2517–20.CrossRefGoogle Scholar
  27. 27.
    Connolly LP, Treves ST, Connolly SA, et al. Vesicoureteric reflux in children: incidence and severity in siblings. J Urol. 1997;157(6):2287–90.PubMedCrossRefGoogle Scholar
  28. 28.
    Nash D. The development of micturition control with special reference to enuresis. Ann R Coll Surg Eng. 1949;5:318–44.Google Scholar
  29. 29.
    Flynn JT, Alderman MH. Characteristics of children with primary hypertension seen at a referral center. Pediatr Nephrol. 2005;20(7):961–6.PubMedCrossRefGoogle Scholar
  30. 30.
    Rianthovorn P, Ettenger RB. Medication non-adherence in the adolescent renal transplant recipient: a clinician’s viewpoint. Pediatr Transplant. 2005;9(3):398–407.CrossRefGoogle Scholar
  31. 31.
    Foster BJ, Leonard MB. Nutrition in children with kidney disease: pitfalls of popular assessment methods. Perit Dial Int. 2005;25 Suppl 3:S143–6.PubMedGoogle Scholar
  32. 32.
    Gavrilovici C, Goldsmith DJ, Reid C. What is the role of ambulatory BP monitoring in pediatric nephrology? J Nephrol. 2004;17(5):642–52.PubMedGoogle Scholar
  33. 33.
    Merten DF, Kirks DR. Diagnostic imaging of paediatric abdominal masses. Pediatr Clin North Am. 1985;32:1397–425.PubMedGoogle Scholar
  34. 34.
    Ikeda M, Ito S, Hataya H, et al. Reversible posterior leukoencephalopathy in a patient with minimal change nephrotic syndrome. Am J Kidney Dis. 2001;37(4):E30.PubMedCrossRefGoogle Scholar
  35. 35.
    Ishikura M, Ikeda M, Hamasaki Y, et al. Posterior reversible leukoencephalopathy syndrome in children: its high prevalence and more extensive imaging findings. Am J Kidney Dis. 2006;48(2):231–8.PubMedCrossRefGoogle Scholar
  36. 36.
    Webb NJA, Coulthard MG, Trompeter RS, et al. Correlation between finger-prick and venous ciclosporin levels: association with gingival overgrowth and hypertrichosis. Pediatr Nephrol. 2007;22:2111–8.PubMedCrossRefGoogle Scholar
  37. 37.
    Berlyne GM, Shaw AB. Red eyes in renal failure. Lancet. 1967;i:4–7.CrossRefGoogle Scholar
  38. 38.
    Deshpande SA, Watson H. Renal ultrasonography not required in babies with isolated minor ear anomalies. Arch Dis Child Fetal Neonatal Ed. 2006;91(1):F29–30.PubMedCentralPubMedCrossRefGoogle Scholar
  39. 39.
    Currarino G, Coln D, Votteler G. Triad of anorectal, sacral and presacral anomalies. AJR Am J Roentgenol. 1981;137(2):395–8.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Pediatric NephrologyRoyal Manchester Children’s HospitalManchesterUK

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