Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cell Biology

  • Filippo Acconcia
  • Rakesh Kumar
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_992-2

Definition

Cell biology deals with all aspects of the normal and of the tumor cell, their normal and abnormal multiplication, their differentiation, their stem origins, and their regulated cell death.

Characteristics

The Cell

The intracellular environment is separated from the external environment by a lipid bilayer called plasma membrane. The plasma membrane controls the movement of substances in and out of the cell and it is important for the cell to sense the surrounding environment. Within the cell the nucleus occupies most of the space. The cell nucleus contains genes, which drive all cellular activities and processes. Genes are organized in chromosomes (i.e., genome) and are made of DNA. The genetic information is used to produce proteins, which are the critical effectors required for all cellular processes. The nucleus is separated from the rest of the cellular content by the nuclear membrane, which remains in contact with the cytoplasm as well as the nucleoplasm. In the...

Keywords

Stem Cell Focal Adhesion Kinase Adult Stem Cell Stem Cell Biology Human Embryonic Stem Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Feinberg AP, Tycko B (2004) The history of cancer epigenetics. Nat Rev Cancer 4:143–153CrossRefPubMedGoogle Scholar
  2. Gearhart J, Hogan B, Melton D et al (2006) Essential of stem cell biology. Academic, LondonGoogle Scholar
  3. Lowe SW, Cepero E, Evan G (2004) Intrinsic tumour suppression. Nature 432:307–315CrossRefPubMedGoogle Scholar
  4. Pestell RG, Albanese C, Reutens AT et al (1999) The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation. Endocr Rev 20:501–534PubMedGoogle Scholar
  5. Potten C, Wilson J (2004) Apoptosis – the life and death of cells. Cambridge University Press, New YorkGoogle Scholar

See Also

  1. (2012) Cell Cycle. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 737. doi: 10.1007/978-3-642-16483-5_994Google Scholar
  2. (2012) Extracellular Matrix. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1362. doi: 10.1007/978-3-642-16483-5_2067Google Scholar
  3. (2012) Microenvironment. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2296. doi: 10.1007/978-3-642-16483-5_3720Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Filippo Acconcia
    • 1
  • Rakesh Kumar
    • 1
  1. 1.Molecular and Cellular OncologyThe University of Texas M. D. Anderson Cancer CenterHoustonUSA