Living reference work entry
Celastrol is a natural quinone methide friedelane tripterene, widely found in the plant genera Celastrus, Maytenus, and Tripterygium, all of which are present in China. For example, celastrol is one of the active components extracted from Tripterygium wilfordii Hook F, an ivy-like vine also known as “Thunder of God Vine,” which belongs to the family of Celastraceae and has been used as a natural medicine in China for hundreds of years (Fig. 1).
KeywordsAndrogen Receptor Tripterygium Wilfordii Chinese Traditional Medicinal Product Celastrol Treatment Glomerella Cingulata
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- Sethi G, Ahn KS, Pandey MK et al (2006) Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-?B-regulated gene products and TAK1-mediated NF-?B activation. Blood 109:2727–2735Google Scholar
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