Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

CEACAM1 Adhesion Molecule

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_979-3

Synonyms

Definition

CEACAM1 (CEA-related cell adhesion molecule 1) belongs to the CEA (carcinoembryonic antigen, CEA gene family) family of cell surface glycoproteins, a subfamily of the immunoglobulin gene superfamily. The CEA family comprises two major groups, the CEA-related molecules and the PSG (pregnancy-specific glycoprotein)-related molecules. Additionally, a number of pseudogenes have been identified. To date, 29 genes are known, which are clustered on human chromosome 19 (19q13.1-19q13.2). The CEA-related members of the CEA family display a complex expression pattern on human healthy and malignant tissues. They are linked to the cell membrane via GPI anchors, or they are transmembrane proteins with a cytoplasmatic tail. The PSG-related molecules are soluble glycoproteins; their expression is...

Keywords

Biliary Tract Disease Lumen Formation Epidermal Growth Factor Receptor Ligand Short Cytoplasmic Tail CEACAM1 Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Inst. Experimental Immunology and HepatologyUniversity Medical Center Hamburg-EppendorfHamburgGermany
  2. 2.University Medical Center Hamburg EppendorfHamburgGermany