Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

CEACAM1 Adhesion Molecule

  • Andrea Kristina Horst
  • Christoph Wagener
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_979-3



CEACAM1 (CEA-related cell adhesion molecule 1) belongs to the CEA (carcinoembryonic antigen, CEA gene family) family of cell surface glycoproteins, a subfamily of the immunoglobulin gene superfamily. The CEA family comprises two major groups, the CEA-related molecules and the PSG (pregnancy-specific glycoprotein)-related molecules. Additionally, a number of pseudogenes have been identified. To date, 29 genes are known, which are clustered on human chromosome 19 (19q13.1-19q13.2). The CEA-related members of the CEA family display a complex expression pattern on human healthy and malignant tissues. They are linked to the cell membrane via GPI anchors, or they are transmembrane proteins with a cytoplasmatic tail. The PSG-related molecules are soluble glycoproteins; their expression is...


Biliary Tract Disease Lumen Formation Epidermal Growth Factor Receptor Ligand Short Cytoplasmic Tail CEACAM1 Expression 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Inst. Experimental Immunology and HepatologyUniversity Medical Center Hamburg-EppendorfHamburgGermany
  2. 2.University Medical Center Hamburg EppendorfHamburgGermany