Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

CD Antigens

  • Richard I. Christopherson
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_947-2

Synonyms

Definition

The human clusters of differentiation (CD) antigens are surface molecules originally detected on white blood cells (leukocytes) from peripheral blood. The first Human Leukocyte Differentiation Antigen (HLDA) workshop was held in Paris in 1982 where 15 surface molecules were assigned based upon the “clustering” of submitted antibodies whose reactivities were screened against a panel of cell lines. Different antibodies that showed similar or identical patterns of reactivity against the panel of cell types were considered to be reacting with the same surface molecule. This clustering of antibody reactivity enabled designation of a specific CD number for a particular surface molecule. The identification of CD antigens was facilitated by the prior development by Kohler and Milstein of a procedure for generation of monoclonal antibodies against a particular antigen....

Keywords

Acute Myeloid Leukemia Chronic Lymphocytic Leukemia Genetic Program Surface Molecule Therapeutic Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Belov L, Mulligan SP, Barber N et al (2006) Analysis of human leukaemias and lymphomas using extensive immunophenotypes from an antibody microarray. Br J Haematol 135:184–197CrossRefPubMedGoogle Scholar
  2. Chattopadhyay PK, Price DA, Harper TF et al (2006) Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry. Nat Med 12:972–977CrossRefPubMedGoogle Scholar
  3. Köhler G, Milstein C (2005) Continuous cultures of fused cells secreting antibody of predefined specificity. J Immunol 174:2453–2455. Reprinted from Nature 256(5517):495–497 (1975)PubMedGoogle Scholar
  4. Zola H, Swart B, Banham A et al (2006) CD molecules – human cell differentiation molecules. J Immunol Methods 319:1–5CrossRefPubMedGoogle Scholar

See Also

  1. (2012) CD Antibody Microarray. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 689. doi:10.1007/978-3-642-16483-5_946Google Scholar
  2. (2012) Clustering. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 885. doi:10.1007/978-3-642-16483-5_1226Google Scholar
  3. (2012) Immunophenotype. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1826. doi:10.1007/978-3-642-16483-5_3000Google Scholar
  4. (2012) Leukocytes. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2028. doi:10.1007/978-3-642-16483-5_3330Google Scholar
  5. (2012) Monoclonal Antibody. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2367. doi:10.1007/978-3-642-16483-5_6842Google Scholar
  6. (2012) Proteomic Techniques. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3100. doi:10.1007/978-3-642-16483-5_4820Google Scholar
  7. (2012) Surface Glycoproteins. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3571. doi:10.1007/978-3-642-16483-5_5593Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.School of Life and Environmental SciencesUniversity of SydneySydneyAustralia