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Encyclopedia of Cancer pp 1–6Cite as

CD Antigens

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Synonyms

Cellular antigens; Cluster of differentiation antigens; Immunophenotypic determinants; Surface molecules

Definition

The human clusters of differentiation (CD) antigens are surface molecules originally detected on white blood cells (leukocytes) from peripheral blood. The first Human Leukocyte Differentiation Antigen (HLDA) workshop was held in Paris in 1982 where 15 surface molecules were assigned based upon the “clustering” of submitted antibodies whose reactivities were screened against a panel of cell lines. Different antibodies that showed similar or identical patterns of reactivity against the panel of cell types were considered to be reacting with the same surface molecule. This clustering of antibody reactivity enabled designation of a specific CD number for a particular surface molecule. The identification of CD antigens was facilitated by the prior development by Kohler and Milstein of a procedure for generation of monoclonal antibodies against a particular antigen....

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References

  • Belov L, Mulligan SP, Barber N et al (2006) Analysis of human leukaemias and lymphomas using extensive immunophenotypes from an antibody microarray. Br J Haematol 135:184–197

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  • Köhler G, Milstein C (2005) Continuous cultures of fused cells secreting antibody of predefined specificity. J Immunol 174:2453–2455. Reprinted from Nature 256(5517):495–497 (1975)

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  • Zola H, Swart B, Banham A et al (2006) CD molecules – human cell differentiation molecules. J Immunol Methods 319:1–5

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See Also

  • (2012) CD Antibody Microarray. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 689. doi:10.1007/978-3-642-16483-5_946

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  • (2012) Clustering. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 885. doi:10.1007/978-3-642-16483-5_1226

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  • (2012) Immunophenotype. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1826. doi:10.1007/978-3-642-16483-5_3000

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  • (2012) Leukocytes. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2028. doi:10.1007/978-3-642-16483-5_3330

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  • (2012) Monoclonal Antibody. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2367. doi:10.1007/978-3-642-16483-5_6842

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  • (2012) Proteomic Techniques. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3100. doi:10.1007/978-3-642-16483-5_4820

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  • (2012) Surface Glycoproteins. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3571. doi:10.1007/978-3-642-16483-5_5593

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Authors and Affiliations

  1. School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia

    Richard I. Christopherson

Authors
  1. Richard I. Christopherson
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Correspondence to Richard I. Christopherson .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Christopherson, R.I. (2014). CD Antigens. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_947-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_947-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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