Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

CD26/DPPIV in Cancer Progression and Spread

  • Jonathan Blay
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_925-2



CD26/DPPIV is a multifunctional protein in the outer membrane of normal and cancer cells that can (i) remove an amino-terminal dipeptide from many regulatory peptides, terminating their activity, (ii) bind the enzyme adenosine deaminase (ADA) from the extracellular fluid, and (iii) associate directly with proteins of the extracellular matrix. Levels of CD26/DPPIV are variable but typically decline as cancer develops, and this has been linked to disease progression and the shift to metastasis.


CD26/DPPIV is a molecule that has been known in different forms since the 1960s but whose key role in cancer has only been appreciated since the early 1990s when it was shown that the absence or presence of CD26/DPPIV in melanocytes determined whether or not those cells showed behavior that was characteristic of a cancer ( melanoma). Our understanding of CD26/DPPIV has an interesting history, as it reflects the...


Purine Nucleoside Adenosine Level Circulate Cancer Cell Directing Cell Movement Call Lymph Node 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of PharmacologyDalhousie UniversityHalifaxCanada