Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Caspase-8

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_875-2

Synonyms

Definition

Caspase-8 belongs to the family of cysteine proteases called caspases that act as mediators of programmed cell death (apoptosis). It is a protein of 480 amino acids and 55 kDa that is widely expressed in various tissues. Caspase-8 displays 20 % identity to the ced-3-encoded protein of Caenorhabditis elegans. The gene maps to 2q33.

Characteristics

Structure and Physiological Functions of Caspase-8

Caspase-8 contains two death-effector domains (DED) in the N-terminal prodomain that serve as protein–protein interaction sites and a catalytic protease domain at the C-terminus consisting of a large and small subunit. The active caspase-8 molecule is composed of a heterotetramer of two of each of the large and small subunits (Fig. 1). The preferred substrate specificity for caspase-8 is I/L/V/E X D (where X is any amino acid).

Keywords

Ewing Sarcoma Trail Receptor Downstream Effector Caspases Activate Death Receptor Agonistic Trail Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Barnhart BC, Lee JC, Alappat EC et al (2003) The death effector domain protein family. Oncogene 22:8634–8644CrossRefPubMedGoogle Scholar
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  4. Park SM, Schickel R, Peter ME (2005) Nonapoptotic functions of FADD-binding death receptors and their signaling molecules. Curr Opin Cell Biol 17:610–616CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Alternative RNA Splicing. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 148. doi:10.1007/978-3-642-16483-5_212Google Scholar
  2. (2012) BH3-Interacting Death Domain Agonist. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 389. doi:10.1007/978-3-642-16483-5_601Google Scholar
  3. (2012) C-FLICE-like Inhibitory Protein. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 753. doi:10.1007/978-3-642-16483-5_1039Google Scholar
  4. (2012) Death Domain. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1065. doi:10.1007/978-3-642-16483-5_1534Google Scholar
  5. (2012) Death-Effector-Domain. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1066. doi:10.1007/978-3-642-16483-5_1535Google Scholar
  6. (2012) Death-Inducing Signaling Complex. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1066. doi:10.1007/978-3-642-16483-5_1536Google Scholar
  7. (2012) Fas Associated with a Death Domain. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1379. doi:10.1007/978-3-642-16483-5_2123Google Scholar
  8. (2012) Initiator Caspases. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1865. doi:10.1007/978-3-642-16483-5_3061Google Scholar
  9. (2012) Microenvironment. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2296. doi:10.1007/978-3-642-16483-5_3720Google Scholar
  10. (2012) PEST Sequence. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2828. doi:10.1007/978-3-642-16483-5_4478Google Scholar
  11. (2012) Phosphoprotein Enriched in Diabetes/Phosphoprotein Enriched in Astrocytes-15kDa. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2870. doi:10.1007/978-3-642-16483-5_4543Google Scholar
  12. (2012) Receptor for TNF-Related Apoptosis-Inducing Ligand. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3198. doi: 10.1007/978-3-642-16483-5_4981Google Scholar
  13. (2012) STAT. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3502. doi:10.1007/978-3-642-16483-5_5481Google Scholar
  14. (2012) Tumor Suppressor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3803. doi:10.1007/978-3-642-16483-5_6056Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Institute for Experimental Cancer Research in PediatricsGoethe-University FrankfurtFrankfurtGermany