Skip to main content
SpringerLink
Log in

Carcinoid Tumors

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 40 Accesses

Synonyms

Argentaffin carcinoma; Carcinoid; NET; Neuroectodermal tumor; Neuroendocrine carcinoma;

Definition

Carcinoid tumors represent a family of diseases derived from neuroendocrine cells. These tumors were first described by Langhans in 1867 but were not described in detail until Lubarsch described them in 1888. The name karzinoide was not used until 1907 by Oberndorfer and was chosen to reflect his idea that these were benign growths. However, these tumors have a wide range of clinical presentations and outcomes from benign to malignant. Clinicians must recognize the nature of carcinoid disease, because these often have a significantly different clinical course than typical carcinomas occurring within the body. Additionally, with few exceptions, neuroendocrine tumors (NETs) comprise a tiny fraction of tumors within any specific organ. These neoplasms cause <1 % of all malignancies in the United States, currently occurring at a rate of 2.5–4.5/100,000 people.

NETs can arise in...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Dreijerink KM, Hoppener JW, Timmers HM et al (2006) Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation. Nat Clin Pract Endocrinol Metab 2(10):562–570

    Article  CAS  PubMed  Google Scholar 

  • Katona TM, Jones TD, Wang M et al (2006) Molecular evidence for independent origin of multifocal neuroendocrine tumors of the enteropancreatic axis. Cancer Res 66(9):4936–4942

    Article  CAS  PubMed  Google Scholar 

  • Kytola S, Hoog A, Nord B et al (2001) Comparative genomic hybridization identifies loss of 18q22-qter as an early and specific event in tumorigenesis of midgut carcinoids. Am J Pathol 158(5):1803–1808

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Modlin IM, Lye KD, Kidd M (2003) A 5-decade analysis of 13,715 carcinoid tumors. Cancer 97(4):934–959

    Article  PubMed  Google Scholar 

  • Walch AK, Zitzelsberger HF, Aubele MM et al (1998) Typical and atypical carcinoid tumors of the lung are characterized by 11q deletions as detected by comparative genomic hybridization. Am J Pathol 153(4):1089–1098

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

    Phillip H. Abbosh & Liang Cheng

Authors
  1. Phillip H. Abbosh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Liang Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Phillip H. Abbosh .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Abbosh, P.H., Cheng, L. (2015). Carcinoid Tumors. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_847-2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-27841-9_847-2

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation