Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cancer Germline Antigens

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_809-2

Synonyms

Definition

CG antigens (cancer-testis (CT) antigens) are a class of immunogenic tumor antigens encoded by genes expressed in gametogenic cells of the testis and/or ovary and in human cancer.

Characteristics

Identification

The main criterion for the classification of a gene as a CG antigen pertains to its expression pattern in gametogenic, somatic, and tumor tissues. A gene is generally considered to be a CG antigen if it is expressed in the gametogenic cells of the testis or ovary (including fetal ovary) and in some proportion of human cancers, but is expressed in two or fewer normal somatic tissues. CG antigen genes are also commonly expressed in trophoblast tissue. CG antigens were originally identified from searches for autoantigens expressed in human cancer. The original method for antigen screening used autologous typing, in which T-cells (T-lymphocyte) from a melanomapatient were screened for reactivity with tumor cells from the same...

Keywords

Melanoma Antigen Germ Cell Maturation Gene Cell Tumor Histone Modification Status Identify Tumor Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Davis ID, Chen W, Jackson H et al (2004) Recombinant NY-ESO-1 protein with ISOMATRIX adjuvant induces broad integrated antibody and CD4+ and CD8+ T cell responses in humans. Proc Natl Acad Sci U S A 101:10697–10702CrossRefPubMedPubMedCentralGoogle Scholar
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  4. Simpson AJG, Caballero OL, Jungbluth A et al (2005) Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer 5:615–625CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Adjuvant. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 75. doi: 10.1007/978-3-642-16483-5_107Google Scholar
  2. (2012) Antibody. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 208. doi: 10.1007/978-3-642-16483-5_312Google Scholar
  3. (2012) Antigen. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 209. doi: 10.1007/978-3-642-16483-5_319Google Scholar
  4. (2012) Autologous Typing. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 317. doi: 10.1007/978-3-642-16483-5_482Google Scholar
  5. (2012) Chromatin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 825. doi: 10.1007/978-3-642-16483-5_1125Google Scholar
  6. (2012) DNA Methylation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1140. doi: 10.1007/978-3-642-16483-5_1682Google Scholar
  7. (2012) Gametogenic. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1493. doi: 10.1007/978-3-642-16483-5_2311Google Scholar
  8. (2012) HLA. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1706. doi: 10.1007/978-3-642-16483-5_2765Google Scholar
  9. (2012) Hypomethylation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1791. doi: 10.1007/978-3-642-16483-5_2922Google Scholar
  10. (2012) P53. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2747. doi: 10.1007/978-3-642-16483-5_4331Google Scholar
  11. (2012) Recombinant. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3205. doi: 10.1007/978-3-642-16483-5_4991Google Scholar
  12. (2012) T Cell. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3599. doi: 10.1007/978-3-642-16483-5_5645Google Scholar
  13. (2012) Trophoblast. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3785. doi: 10.1007/978-3-642-16483-5_5989Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Pharmacology and TherapeuticsRoswell Park Cancer InstituteBuffaloUSA