CAMTA1 is a candidate tumor suppressor gene encoding a member of a protein family designated as calmodulin-binding transcription activators (CAMTAs). It resides within a distal portion of chromosomal arm 1p that is frequently deleted in a wide range of human malignancies.
CAMTA1 maps to 1p36.31-p36.23 and its 23 exons are spread over 982.5 kb. The 6,582 bp cDNA encodes a protein of 1,673 amino acids. The primary structure of protein contains a nuclear localization signal, two DNA-binding domains (CG-1 and TIG), a transcription activation domain, calmodulin binding motifs (IQ motifs), and ankyrin domains. Although the expression of CAMTA1 is seen in various organs, the highest levels are found in neuronal tissues. Information on the physiologic roles of CAMTAs is scarce and most data derive from plant and drosophila studies.
CAMTAs are transcription factors that typically bind to CGCG boxes via their CG-1 domain. An alternative mechanism of transcriptional...
KeywordsPoor Patient Outcome Candidate Tumor Suppressor Gene Transcription Activation Domain Stimulate Gene Expression Fine Mapping Study
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