Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Calcitonin

  • Girish V. Shah
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_776-2

Definition

Calcitonin (CT) is a 32-amino acid peptide synthesized in mammals by the C cells of the thyroid gland. Several extrathyroidal sites including the prostate gland, gastrointestinal tract, thymus, bladder, lung, pituitary gland, and central nervous system (CNS) also produce this peptide molecule (Ball 2007).

Characteristics

Almost all cells of human body synthesize and secrete procalcitonin (proCT), a precursor of the CT peptide, in response to infection/inflammation. Only cells of the thyroid and neuroendocrine organs can process proCT to produce mature CT molecule (Davies 2015). CT sequence among various species shows remarkable divergence (Steinwald et al. 1999). However, all sequences contain 32 amino acids, a carboxy-terminal proline amide, and a disulfide bridge between cysteine residues at positions 1 and 7. In addition to CT, other biologically and chemically diverse molecules such as CT gene-related peptide (CGRP), adrenomedullin(AFP-modern), and amylin (AMY) are...

Keywords

Breast Cancer Cell Line Adenylyl Cyclase Prostate Cancer Cell Line Cytosolic Calcium Level Proline Amide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  9. Thomas S, Chigurupati S, Anbalagan M, Shah G (2006) Calcitonin increases tumorigenicity of prostate cancer cells: evidence for the role of protein kinase A and urokinase-type plasminogen receptor. Mol Endocrinol 20(8):1894–1911CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of PharmacologyUniversity of Louisiana College of PharmacyMonroeUSA