Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cajal Bodies

  • Vincenzo de Laurenzi
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_772-2

Synonyms

Definition

Small nuclear organelles (0.1–2.0 μM in diameter), present in all eukaryotic cells, involved in a number of different nuclear functions.

Characteristics

The nucleus of eukaryotic cells contains a number of different highly specialized organelles. Unlike cytoplasmic organelles these nuclear structures are not delimited by a membrane but are by all means compartments that contain a number of specific proteins. Most of the organelles can be clearly identified through immunostaining using antibodies directed against specific marker proteins; however, it should be kept in mind that these organelles are highly dynamic structures that often exchange components and therefore many proteins can be found in more than one organelle.

Among these organelles are Cajal bodies (CBs), described over a century ago by Ramon y Cajal. CBs were originally described in neuronal cells but have since been described in a variety of cell types, both in animals and in plants,...

Keywords

Acute Myeloid Leukemia Spinal Muscular Atrophy Spinocerebellar Ataxia Histone Gene Autosomal Recessive Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Cioce M, Lamond AI (2005) Cajal bodies: a long history of discovery. Annu Rev Cell Dev Biol 21:105–131CrossRefPubMedGoogle Scholar
  2. Gall JG (2000) Cajal bodies: the first 100 years. Annu Rev Cell Dev Biol 16:273–300CrossRefPubMedGoogle Scholar
  3. Ogg SC, Lamond AI (2002) Cajal bodies and coilin – moving towards function. J Cell Biol 159(1):17–21CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Experimental Medicine and Biochemical SciencesUniversity of Tor VergataRomeItaly