Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

BRMS1

  • Lellys Mariella Contreras
  • Amanda E. Brinker
  • Danny R. Welch
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_735-3

Definition

BRMS1 is a human metastasis suppressor gene that, when re-expressed, suppresses metastasis of multiple metastatic cell lines of various origins.

Characteristics

BRMS1 is encoded on chromosome 11q13.1-q13.2, spans >8.5 kb, is comprised of ten exons (exon 1 is untranslated), and includes two CpG islands. BRMS1 cDNA is 1485 base pairs and encodes a 246 amino acid protein (MW ~28.5 kDa, although it runs more slowly (Mr ~35 kDa) by SDS-PAGE). The mouse orthologue (Brms1) shares 95 % homology at the amino acid level and also suppresses metastasis in murine models of breast cancer. BRMS1 protein contains two putative nuclear localization sequences, a nuclear export sequence, a potential endoplasmic retention signal, two coiled-coil motifs, a CXD motif with E3 ligase activity, imperfect leucine zippers, and a glutamic acid–rich N-terminus. BRMS1 is ubiquitously expressed in human tissues (highest in kidney, placenta, peripheral blood lymphocytes, and testis; lowest in brain and...

Keywords

Circulate Tumor Cell Metastasis Suppressor Nuclear Localization Sequence Metastasis Suppressor Gene Endoplasmic Retention 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Balgkouranidou I, Chimonidou M, Milaki G et al (2014) Breast cancer metastasis suppressor-1 promoter methylation in cell-free DNA provides prognostic information in non-small cell lung cancer. Br J Cancer 110:2054–2062PubMedCentralCrossRefPubMedGoogle Scholar
  2. Edmonds MD, Hurst DR, Vaidya KS, Stafford LJ, Chen D, Welch DR (2009) Breast cancer metastasis suppressor 1 coordinately regulates metastasis-associated microRNA expression. Int J Cancer 125(8):1778–1785PubMedCentralCrossRefPubMedGoogle Scholar
  3. Hicks DG, Yoder BJ, Short S et al (2006) Loss of breast cancer metastasis suppressor 1 protein expression predicts reduced disease-free survival in subsets of breast cancer patients. Clin Cancer Res 12:6702–6708PubMedCentralCrossRefPubMedGoogle Scholar
  4. Hurst DR, Welch DR (2011) Unraveling the enigmatic complexities of BRMS1-mediated metastasis suppression. FEBS Lett 585:3185–3190PubMedCentralCrossRefPubMedGoogle Scholar
  5. Liu Y, Smith PW, Jones DR (2006) Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis. Mol Cell Biol 26:8683–8696PubMedCentralCrossRefPubMedGoogle Scholar
  6. Liu Y, Mayo MW, Nagji AS et al (2013) BRMS1 suppresses lung cancer metastases through an E3 ligase function on histone acetyltransferase p300. Cancer Res 73:1308–1317PubMedCentralCrossRefPubMedGoogle Scholar
  7. Meehan WJ, Samant RS, Hopper JE et al (2004) Interaction of the BRMS1 metastasis suppressor with RBP1 and the mSin3 histone deacetylase complex. J Biol Chem 279:1562–1569CrossRefPubMedGoogle Scholar
  8. Samant RS, Clark DW, Fillmore RA et al (2007) Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation. Mol Cancer 6:6PubMedCentralCrossRefPubMedGoogle Scholar

See Also

  1. (2012) Experimental Metastasis. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1361. doi: 10.1007/978-3-642-16483-5_2062Google Scholar
  2. (2012) Lung Colony Formation Assay. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2115. doi: 10.1007/978-3-642-16483-5_3436Google Scholar
  3. (2012) Macrometastasis. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2130. doi: 10.1007/978-3-642-16483-5_3483Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Lellys Mariella Contreras
    • 1
  • Amanda E. Brinker
    • 1
  • Danny R. Welch
    • 1
  1. 1.Department of Cancer BiologyUniversity of Kansas Cancer Center, The University of Kansas Medical CenterKansas CityUSA