Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Lellys Mariella Contreras
  • Amanda E. Brinker
  • Danny R. Welch
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_735-3


BRMS1 is a human metastasis suppressor gene that, when re-expressed, suppresses metastasis of multiple metastatic cell lines of various origins.


BRMS1 is encoded on chromosome 11q13.1-q13.2, spans >8.5 kb, is comprised of ten exons (exon 1 is untranslated), and includes two CpG islands. BRMS1 cDNA is 1485 base pairs and encodes a 246 amino acid protein (MW ~28.5 kDa, although it runs more slowly (Mr ~35 kDa) by SDS-PAGE). The mouse orthologue (Brms1) shares 95 % homology at the amino acid level and also suppresses metastasis in murine models of breast cancer. BRMS1 protein contains two putative nuclear localization sequences, a nuclear export sequence, a potential endoplasmic retention signal, two coiled-coil motifs, a CXD motif with E3 ligase activity, imperfect leucine zippers, and a glutamic acid–rich N-terminus. BRMS1 is ubiquitously expressed in human tissues (highest in kidney, placenta, peripheral blood lymphocytes, and testis; lowest in brain and...


Circulate Tumor Cell Metastasis Suppressor Nuclear Localization Sequence Metastasis Suppressor Gene Endoplasmic Retention 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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See Also

  1. (2012) Experimental Metastasis. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1361. doi: 10.1007/978-3-642-16483-5_2062Google Scholar
  2. (2012) Lung Colony Formation Assay. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2115. doi: 10.1007/978-3-642-16483-5_3436Google Scholar
  3. (2012) Macrometastasis. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2130. doi: 10.1007/978-3-642-16483-5_3483Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Lellys Mariella Contreras
    • 1
  • Amanda E. Brinker
    • 1
  • Danny R. Welch
    • 1
  1. 1.Department of Cancer BiologyUniversity of Kansas Cancer Center, The University of Kansas Medical CenterKansas CityUSA