Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Childhood Cancer and Pediatric Cancer Predisposition Syndromes

  • Stefan K. Zöllner
  • Jeffrey A. Toretsky
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7234-1


Genetic factors play a crucial role in the development of cancer. There are several genetic conditions which are associated with increased risk of cancers, termed hereditary cancer syndromes. In adults, the percentage of cancer attributed to underlying, inherited genetic mutations is estimated at 5–10 %. However, the rate of cancer predisposition in children might be significantly higher, and potentially as high as a third of all new pediatric cancer diagnoses may be due to an inherited genetic cause. Identification of at-risk individuals leads to early tumor detection and better prognosis for some cancers. Familial neoplastic syndromes, bone marrow failure syndromes, inherited immunodeficiency (see Immunosuppression and Cancer), and numerical chromosome abnormalities are presented.


Hereditary Cancer Predisposition Syndromes

Although hereditary cancer predisposition syndromes are rare, the list of well-defined inherited cancer predisposition syndromes is...


Tuberous Sclerosis Complex Multiple Endocrine Neoplasia Type Fanconi Anemia Testicular Germ Cell Tumor Adenomatous Polyposis Coli Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Pediatric Hematology and OncologyUniversity Childrens Hospital MünsterMünsterGermany
  2. 2.Department of Oncology and Pediatrics, Lombardi Comprehensive Cancer CenterGeorgetown UniversityWashingtonUSA