Childhood Cancer and Pediatric Cancer Predisposition Syndromes
Genetic factors play a crucial role in the development of cancer. There are several genetic conditions which are associated with increased risk of cancers, termed hereditary cancer syndromes. In adults, the percentage of cancer attributed to underlying, inherited genetic mutations is estimated at 5–10 %. However, the rate of cancer predisposition in children might be significantly higher, and potentially as high as a third of all new pediatric cancer diagnoses may be due to an inherited genetic cause. Identification of at-risk individuals leads to early tumor detection and better prognosis for some cancers. Familial neoplastic syndromes, bone marrow failure syndromes, inherited immunodeficiency (see Immunosuppression and Cancer), and numerical chromosome abnormalities are presented.
Hereditary Cancer Predisposition Syndromes
Although hereditary cancer predisposition syndromes are rare, the list of well-defined inherited cancer predisposition syndromes is...