Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Childhood Cancer and Treatment-Related Toxicities

  • Stefan K. Zöllner
  • Jeffrey A. Toretsky
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7233-1


Treatment-related toxicities of childhood cancer encompass both the physical and non-physical burden of children and young adolescents diagnosed with cancer which result from invasive and non-invasive medical treatment modalities and the psycho-socio-economic effects of being a cancer patient, occurring during and/or after the disease-related treatment.

Risk awareness

The overall survival rates of many pediatric cancers continue to improve with each decade due to new advances in therapy. As this trend continues, the focus and importance of minimizing acute and long-term toxicity associated with treatment is paramount; significant treatment-related toxicities continue to impact the majority of children with cancer. Awareness of short- and long-term health risks is important, and careful follow-up of long-term survivors is essential. Children with cancer and their families are affected not only by the disease and treatments but also by significant effects on the child’s...


Acute Myeloid Leukemia Hematopoietic Stem Cell Transplantation Papillary Thyroid Carcinoma Ionize Radiation Therapy Childhood Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.


  1. Armenian SH, Kremer L.C, Sklar C (2015) Approaches to reduce the long-term burden of treatment-related complications in survivors of childhood cancer. Am Soc Clin Oncol Educ Book 196–204Google Scholar
  2. Bhatia S, Sklar C (2002) Second cancers in survivors of childhood cancer. Nat Rev Cancer 2(2):124–132CrossRefPubMedGoogle Scholar
  3. Landier W, Armenian S, Bhatia S (2015) Late effects of childhood cancer and its treatment. Pediatr Clin North Am 62(1):275–300CrossRefPubMedGoogle Scholar
  4. Lipshultz SE et al (2013) Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions: a scientific statement from the American Heart Association. Circulation 128(17):1927–1995CrossRefPubMedGoogle Scholar
  5. Oeffinger KC et al (2006) Chronic health conditions in adult survivors of childhood cancer. N Engl J Med 355(15):1572–1582CrossRefPubMedGoogle Scholar
  6. Prasad PK et al (2015) Psychosocial and neurocognitive outcomes in adult survivors of adolescent and early young adult cancer: a report from the childhood cancer survivor study. J Clin Oncol 33(23):2545–2552CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Pediatric Hematology and OncologyUniversity Childrens Hospital MünsterMünsterGermany
  2. 2.Department of Oncology and Pediatrics, Lombardi Comprehensive Cancer CenterGeorgetown UniversityWashingtonUSA