Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Necrosis

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7231-1

Synonyms

Definition

Necrosis is a form of cell death which is distinguished by a number of morphological changes typically rounding of the plasma and cell organelle membranes, plasma membrane dysfunction and cytoplasmic swelling, plasma membrane rupture, and spilling of intracellular contents. Necrosis is commonly described as being accidental or premature, involving an initial trigger then inflammation, and is predominantly detrimental, often fatal, to the organism. This type of cell death is viewed as the opposite to apoptosis, which can be localized to a single cell, does not stimulate the immune system, and is usually beneficial and often essential to the organism. In short, necrosis is typically described as being a disorderly form of cell death. The necrotic death of a cell can induce the necrosis of surrounding cells due to the cell constituents released by the dying cell, so necrosis can spread if left untreated. A good example of the danger of...

Keywords

Cytotoxic Drug Necrotic Cell Death Secondary Necrosis Spider Venom Necrotic Death 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Linkermann A et al (2012) Programmed necrosis in acute kidney injury. Nephrol Dial Transplant Oxf J 27:3412–3419CrossRefGoogle Scholar
  2. Silva MT (2010) Secondary necrosis: the natural outcome of the complete apoptotic program. FEBS Lett 584(22):4491–4499CrossRefPubMedGoogle Scholar
  3. Vanden Berghe T et al (2009) Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features. Nature Cell Death Differ 17:922–930CrossRefGoogle Scholar

See Also

  1. (2012) Enzyme. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1259. doi: 10.1007/978-3-642-16483-5_1917
  2. (2012) Immune system. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1815. doi: 10.1007/978-3-642-16483-5_2980
  3. (2012) Ischemia. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1917. doi: 10.1007/978-3-642-16483-5_3151
  4. (2012) Mitochondrium. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2336. doi: 10.1007/978-3-642-16483-5_3768
  5. (2012) Plasma membrane. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2900. doi: 10.1007/978-3-642-16483-5_4599

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.University of AberdeenAberdeenUK
  2. 2.Cell ProTxAberdeenUK