Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Colorectal Cancer Chemoprevention

Living reference work entry
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DOI: https://doi.org/10.1007/978-3-642-27841-9_7223-1
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Synonyms

Adenomatous polyps; COX-2 inhibitors; Therapeutic prevention

Definition

Chemoprevention involves the use of drugs (of synthetic or natural origin) in order to delay, reverse, or prevent disease progression. The chemoprevention concept is not a new medical intervention and has been used for decades with remarkable success as part of risk reduction approaches for cardiovascular disease. Diseases with a long latency period, such as colorectal cancer, provide an ideal scenario for the application of chemopreventive strategies with a considerable potential to improve patient outcomes. However, in order to determine whether such a strategy may be truly beneficial within this paradigm, two research areas need to experience significant advances. Firstly, our understanding of the natural progression of the disease and underlying molecular and genetic changes needs to be improved further, and secondly, robust and easily measurable biomarkers need to be discovered and developed for...

Keywords

Colorectal Cancer Familial Adenomatous Polyposis Lynch Syndrome Aberrant Crypt Focus Colorectal Cancer Risk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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See Also

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  31. (2012) Polyp. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2955. doi:10.1007/978-3-642-16483-5_6524Google Scholar
  32. (2012) Primary cancer prevention. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2985. doi:10.1007/978-3-642-16483-5_4731Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Cancer StudiesUniversity of LeicesterLeicesterUK