Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Klotho Tumor Suppressor

  • Tami Rubinek
  • Ido Wolf
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7219-1

Definition

Klotho (α-klotho) is implicated in the aging process and participates in metabolic activities including maintaining phosphate and calcium homeostasis. Klotho is expressed in various tissues, with highest expression in the kidney and brain. It is located in the cell membrane but can also be shed and act as a circulating hormone. Different activities of klotho have been described and include regulation of major signaling pathways including the fibroblast growth factor (FGF), insulin-like growth factor (IGF-1), and the Wnt pathways. Accumulating data indicate klotho as a potent tumor suppressor in a wide array of malignancies. Klotho expression is downregulated in cancer tissues, primarily through epigenetic mechanisms, and reduced expression is associated with adverse clinical characteristics and prognosis. Reintroduction of klotho to cancer cells inhibits signaling pathways critical for tumorigenesis, leading to reduced proliferation, motility, and invasion capacity. In vivo...

Keywords

Pancreatic Cancer Esophageal Carcinoma Klotho Gene Transient Receptor Potential Cation Channel Klotho Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Abramovitz L, Rubinek T, Ligumsky H, Bose S, Barshack I, Avivi C, Kaufman B, Wolf I (2011) KL1 internal repeat mediates klotho tumor suppressor activities and inhibits bFGF and IGF-I signaling in pancreatic cancer. Clin Cancer Res 17:4254–4266CrossRefPubMedGoogle Scholar
  2. Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H et al (2005) Suppression of aging in mice by the hormone klotho. Science 309:1829–1833CrossRefPubMedPubMedCentralGoogle Scholar
  3. Wolf I, Levanon-Cohen S, Bose S, Ligumsky H, Sredni B, Kanety H, Kuro-o M, Karlan B, Kaufman B, Koeffler HP et al (2008) Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene 27:7094–7105CrossRefPubMedGoogle Scholar
  4. Xie B, Chen J, Liu B, Zhan J (2013) Klotho acts as a tumor suppressor in cancers. Pathol Oncol Res 19:611–7CrossRefPubMedGoogle Scholar

See Also

  1. (2012) AKT. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 115. doi:10.1007/978-3-642-16483-5_163Google Scholar
  2. (2012) Beta-catenin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 385. doi:10.1007/978-3-642-16483-5_889Google Scholar
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  4. (2012) ERK. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 1307–1308. doi:10.1007/978-3-642-16483-5_1987Google Scholar
  5. (2012) Hypermethylation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1784. doi:10.1007/978-3-642-16483-5_2910Google Scholar
  6. (2012) Lymph node metastases. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2116. doi:10.1007/978-3-642-16483-5_3444Google Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Tel Aviv Medical Center and Tel Aviv UniversityTel AvivIsrael