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Encyclopedia of Cancer pp 1–3Cite as

RE1-Silencing Transcription Factor

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Synonyms/Acronyms

Neuron-restrictive silencer factor (NRSF); X box repressor (XBR)

Definition

REST stands for RE1-silencing transcription factor and its gene localizes on human chromosome 4q12. REST is a Kruppel-type zinc finger protein, encoded by RESTgene. REST mediates gene repression through binding a DNA sequence motif by recruiting the multiple proteins. The motif that REST binds is called repressor element 1 (RE1) or neuron restrictive silencing element (NRSE). Several thousands of RE1 motifs are reported to regulate hundreds of genes. One group reported that transcription factor named NRSF (neuron-restrictive silencer transcription factor) represses the expression of SCG10 through NRSE element. Another group cloned independently transcriptional repressor REST from a HeLa cell cDNA library. REST is a transcriptional repressor which silences neuronal genes predominantly expressed in nonneuronal cells. REST was originally identified as a master transcriptional repressor of a...

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References

  • Chong JA, Tapia-Ramirez J, Kim S, Toledo-Aral JJ, Zheng Y, Boutros MC, Altshuller YM, Frohman MA, Kraner SD, Mandel G (1995) REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80:949–957

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  • Coulson JM (2005) Transcriptional regulation: cancer, neurons and the REST. Curr Biol 15(17):R665–R668

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  • Schoenherr CJ, Anderson DJ (1995b) Silencing is golden: negative regulation in the control of neuronal gene transcription. Curr Opin Neurobiol 5(5):566–571

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  • Shimojo M, Hersh LB (2004) Regulation of the cholinergic gene locus by the repressor element-1 silencing transcription factor/neuron restrictive silencer factor (REST/NRSF). Life Sci 74(18):2213–2225

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  • Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ (2005) A genetic screen for candidate tumor suppressors identifies REST. Cell 121(6):837–848

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See Also

  • (2012) Alternative RNA splicing. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 148. doi:10.1007/978-3-642-16483-5_212

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Authors and Affiliations

  1. School of Medicine, Osaka Medical College, Takatsuki, Osaka, Japan

    Masahito Shimojo

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  1. Masahito Shimojo
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Correspondence to Masahito Shimojo .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Shimojo, M. (2015). RE1-Silencing Transcription Factor. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7214-1

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_7214-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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