Invadosomes – a single name that is used for podosomes and invadopodia, of which both are specialized F-actin-based adhesive structures formed mostly as cell protrusions at sites of cell–extracellular matrix (ECM) contacts on the ventral membrane of a variety of cell types. It is assumed that invadosomes are referred to as podosomes when they are found in normal cells and as invadopodia when they are found in cancer cells. Invadosomes have the ability to degrade ECM components by regulating the local release and activation of proteases that promote the ability of cells to cross tissue barriers, and this is what mainly distinguishes them from other cell-matrix contact structures such as focal adhesions, lamellipodia, or filopodia.
Invadosomes were first discovered in the 1980s in Rous sarcoma virus (v-Src)-transformed chicken embryo fibroblasts and initially described as rosette-shape adhesions with matrix-degrading ability....
KeywordsLipid Raft Chicken Embryo Fibroblast Plasma Membrane Cholesterol Multiple Pathological Process Branch Actin Network
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