Skip to main content

Antioxidant Enzymes

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

Synonyms

Antioxidants; Enzymes; Free radicals; Oxidative stress; Oxygen toxicity; Reactive oxygen species

Definition

Antioxidant enzymes are proteins involved in the catalytic transformation of reactive oxygen species and their by-products into stable nontoxic molecules therefore representing the most important defense mechanism against oxidative stress-induced cell damage.

Characteristics

In biological chemistry, oxidation is the process by which a molecule loses electrons spontaneously or by metabolic coupled reactions.

In cell metabolism, molecule oxidation provides the driven force toward the production of energy-rich intermediates in the form of ATP. Molecule oxidation may be achieved by enzyme-catalyzed reactions or as a result of electron sequestration induced by specific molecules known as oxidants. Clear examples of oxidants are free radicals which are defined as molecules with unpaired electrons in their upper electron layer which explains their high affinity and tendency to...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Bindoli A, Fukuto JM, Forman HJ (2008) The chemistry of peroxidise and redox signalling. Antioxid Redox Signal 10:1549–1564

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Fridovich I (1999) Fundamental aspects of reactive oxygen species, or what’s the matter with oxygen? Ann N Y Acad Sci 893:13–18

    Article  PubMed  CAS  Google Scholar 

  • Halliwell B, Gutteridge JMC (2007) Free radicals in biology and medicine, 4th edn. Oxford University Press, Oxford, UK

    Google Scholar 

  • McCord JM, Fridovich I (1969) Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 244:6049

    PubMed  CAS  Google Scholar 

See Also

  • (2012) Free radicals. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1454. doi:10.1007/978-3-642-16483-5_2267

    Google Scholar 

  • (2012) Superoxide radical. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3563. doi:10.1007/978-3-642-16483-5_5580

    Google Scholar 

  • (2012) Thioredoxin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3669. doi:10.1007/978-3-642-16483-5_5774

    Google Scholar 

  • (2012) Thioredoxin reductase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2669. doi:10.1007/978-3-642-16483-5_5776

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Guillermo T. Sáez .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Sáez, G.T., Están-Capell, N. (2014). Antioxidant Enzymes. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7210-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-27841-9_7210-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics