Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Pancreatic Cancer Metastasis

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7204-1

Synonyms

Definition

Pancreatic cancer metastasis describes the process that leads to secondary malignant tumor cell growth at distant sites or organs from the parental cancer in the pancreas. Pancreatic cancer is often used as a synonym for pancreatic ductal adenocarcinoma (PDAC), which is the most frequent (>80 %) and most lethal histologic type of cancer arising in the pancreas. Other histologic types are neuroendocrine tumors of the pancreas, acinar cell carcinoma, or adenosquamous carcinoma, which are not referred to in this entry.

Characteristics

Pancreatic cancer is the fourth leading cause of cancer-related death in the Western world, and one main reason for the dismal prognosis is early metastasis to regional lymph nodes and distant organ sites (most frequently to the liver, peritoneum, and lung) (Iacobuzio-Donahue et al. 2009) (Fig. 1). Macroscopically,...

Keywords

Pancreatic Cancer Pancreatic Ductal Adenocarcinoma Lymph Node Ratio Metastatic Process Adenosquamous Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  5. Welsch T, Keleg S, Bergmann F et al (2009) Comparative analysis of tumorbiology and CD133 positivity in primary and recurrent pancreatic ductal adenocarcinoma. Clin Exp Metastasis 26:701–711CrossRefPubMedGoogle Scholar
  6. Yachida S, Jones S, Bozic I et al (2010) Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467:1114–1117PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Visceral, Thoracic and Vascular SurgeryTU DresdenDresdenGermany