Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Ovarian Cancer Stem Cells

  • Roman Mezencev
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7203-1

Synonyms

Definition

Consistent with the cancer stem cell (CSC) hypothesis, ovarian cancer stem cells represent a subset of cancer cells lying at the top of hierarchy of all malignant cells that form the bulk of ovarian cancers. Cancer stem cells display ability to continually sustain tumor growth through their indefinite self-renewal and ability to generate all cancer cell lineages (transit-amplifying cells, differentiated cells) found in particular tumors through their (aberrant) differentiation.

Characteristics

Classification of Ovarian Cancers

Ovarian cancers represent a highly heterogeneous group of diseases with distinct cellular origin, epidemiology, pathogenesis, morphological and molecular characteristics, and clinical course. Considering cell types from which ovarian cancers presumably originate, most ovarian cancers can be classified into three major categories: epithelial (~90 %), sex cord-stromal (~8 %), and...

Keywords

Ovarian Cancer Acute Myeloid Leukemia Cancer Stem Cell Epithelial Ovarian Cancer Adult Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Ahmed N, Abubaker K, Findlay JK (2014) Ovarian cancer stem cells: molecular concepts and relevance as therapeutic targets. Mol Asp Med 39:110–125CrossRefGoogle Scholar
  2. Burgos-Ojeda D, Rueda BR, Buckanovich RJ (2012) Ovarian cancer stem cell markers: prognostic and therapeutic implications. Cancer Lett 322:1–7PubMedCentralPubMedCrossRefGoogle Scholar
  3. Pattabiraman DR, Weinberg RA (2014) Tackling the cancer stem cells – what challenges do they pose? Nat Rev Drug Discov 13:497–512PubMedCentralPubMedCrossRefGoogle Scholar
  4. Shah MJ, Landen CN (2014) Ovarian cancer stem cells: are they real and why are they important? Gynecol Oncol 132:483–489PubMedCentralPubMedCrossRefGoogle Scholar
  5. Visvader JE, Lindeman GJ (2012) Cancer stem cells: current status and evolving complexities. Cancer Stem Cell 10:717–728CrossRefGoogle Scholar

See Also

  1. (2012) Transit amplifying cells. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3766. doi: 10.1007/978-3-642-16483-5_5926Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Georgia Institute of Technology, School of BiologyAtlantaUSA