Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Necroptosis

  • Yong Lin
  • Mabel Padilla
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7202-1

Synonyms

Definition

Necroptosis is a form of regulated or programmed and caspase-independent death in higher eukaryotic cells, in which the dying cells display the features of necrosis including cell swelling, mitochondrial dysfunction, plasma membrane permeabilization, and release of cytoplasmic content to the extracellular space (Zhou and Yuan 2014). Necroptosis can be a substitute form of cell death under apoptotic-deficient conditions. However, necroptosis may also occur when apoptosis is competent. Thus, necroptosis can be either a dominant or an alternate mode of cell death (Zhou and Yuan 2014; Jouan-Lanhouet et al. 2014; Giampietri et al. 2014).

Characteristics

History of Discovery

Necroptosis represents a portion of necrosis or necrotic cell death. Necrosis was discovered long ago and has been considered to be a purely unregulated, uncontrollable, accidental, and passive death process occurring when cells are...

Keywords

Necrotic Cell Death Phosphoglycerate Mutase Mixed Lineage Kinase Necroptotic Cell Death L929 Fibrosarcoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH et al (2009) Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ 16:1093–1107PubMedCentralCrossRefPubMedGoogle Scholar
  2. Giampietri C, Starace D, Petrungaro S, Filippini A, Ziparo E (2014) Necroptosis: molecular signalling and translational implications. Int J Cell Biol 2014:490275PubMedCentralPubMedGoogle Scholar
  3. Imre G, Larisch S, Rajalingam K (2011) Ripoptosome: a novel IAP-regulated cell death-signalling platform. J Mol Cell Biol 3:324–326CrossRefPubMedGoogle Scholar
  4. Jouan-Lanhouet S, Riquet F, Duprez L, Berghe TV, Takahashi N, Vandenabeele P (2014) Necroptosis, in vivo detection in experimental disease models. Semin Cell Dev Biol pii: S1084-9521(14)00246-8. doi:10.1016/j.semcdb.2014.08.010. [Epub ahead of print]Google Scholar
  5. Zhou W, Yuan J (2014) Necroptosis in health and diseases. Semin Cell Dev Biol pii: S1084-9521(14)00224-9. doi:10.1016/j.semcdb.2014.07.013. [Epub ahead of print]Google Scholar

See Also

  1. (2012) Programmed Cell Death. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2994. doi: 10.1007/978-3-642-16483-5_4760Google Scholar
  2. (2012) Receptor for TNF-Related Apoptosis-Inducing Ligand. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3198. doi: 10.1007/978-3-642-16483-5_4981Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Molecular Biology and Lung Cancer ProgramLovelace Respiratory Research InstituteAlbuquerqueUSA