Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Gastric Cancer Therapy

  • Shing Leng ChanEmail author
  • Jimmy BY So
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7199-1


Gastric cancer (GC) is a cancer that arises from the lining of the stomach. More than 95 % of this heterogeneous disease is adenocarcinoma that can be subdivided into two main histological subtypes: intestinal and diffuse, based on Lauren classification.


While the intestinal type of gastric cancer is often related to environmental factors such as Helicobacter pylori infection, diet, and lifestyle, etiology of the diffuse type is more elusive although there is association with genetic abnormalities such as CDH1 mutation in a small population of patients. Furthermore, there is little evidence in the literature that correlates different molecular aberrations among these two disease subtypes, thus diminishing the usefulness of this classification in the prediction of targeted therapy. Therefore, gastric cancer therapy/treatment is still largely dependent on clinical staging of the disease, i.e., early or advance stage.

Therapy of Early Stage Gastric Cancer



Gastric Cancer Vascular Endothelial Growth Factor Human Epidermal Growth Factor Receptor Endoscopic Submucosal Dissection Advanced Gastric Cancer 
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  1. Javle M, Smyth EC, Chau I (2014) Ramucirumab: successfully targeting angiogenesis in gastric cancer. Clin Cancer Res 20:5875–5881PubMedCentralCrossRefPubMedGoogle Scholar
  2. Power DG, Kelsen DP, Shah MA (2010) Advanced gastric cancer – slow but steady progress. Cancer Treat Rev 36:384–392CrossRefPubMedGoogle Scholar
  3. Sakuramoto S, Sasako M, Yamaguchi T et al (2007) Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med 357:1810–1820CrossRefPubMedGoogle Scholar
  4. Takahashi T, Saikawa Y, Kitagawa Y (2013) Gastric cancer: current status of diagnosis and treatment. Cancers (Basel) 5:48–63CrossRefGoogle Scholar
  5. Wong H, Yau T (2013) Molecular targeted therapies in advanced gastric cancer: does tumor histology matter? Ther Adv Gastroenterol 6:15–31CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Cancer Science Institute of SingaporeNational University of SingaporeSingaporeSingapore
  2. 2.Department of SurgeryNational University of Singapore, National University HospitalSingaporeSingapore