Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Steroid Receptor Coactivators

  • Weiwen Long
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7193-1



SRCs are transcriptional coactivators for nuclear hormone receptors (NRs), such as estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR), and for non-NR transcriptional factors, such as Stat3, E2F1, and NFкB.


Functional Domains

The common structure of SRC proteins contains five functional domains/regions: the N-terminal basic helix-loop-helix-Per/ARNT/Sim (bHLH/PAS) domain, the serine/threonine-rich (S/T) domain, the nuclear receptor-interacting domain (RID), the CBP (cAMP-response element binding protein)-interacting domain (CID) or activation domain 1 (AD1), and the activation domain 2 (AD2) at the C-terminus. Each domain interacts with different proteins that confer various functions. The bHLH/PAS domain harbors nuclear localization signals (NLS) and is the most...


Androgen Receptor Steroid Receptor Coactivators Receptor Coactivators Cancer Include Breast Cancer Prostate Cancer Cell Growth 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyWright State UniversityDaytonUSA