Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Steroid Receptor Coactivators

  • Weiwen Long
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7193-1

Synonyms

Definition

SRCs are transcriptional coactivators for nuclear hormone receptors (NRs), such as estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR), and for non-NR transcriptional factors, such as Stat3, E2F1, and NFкB.

Characteristics

Functional Domains

The common structure of SRC proteins contains five functional domains/regions: the N-terminal basic helix-loop-helix-Per/ARNT/Sim (bHLH/PAS) domain, the serine/threonine-rich (S/T) domain, the nuclear receptor-interacting domain (RID), the CBP (cAMP-response element binding protein)-interacting domain (CID) or activation domain 1 (AD1), and the activation domain 2 (AD2) at the C-terminus. Each domain interacts with different proteins that confer various functions. The bHLH/PAS domain harbors nuclear localization signals (NLS) and is the most...

Keywords

Androgen Receptor Steroid Receptor Coactivators Receptor Coactivators Cancer Include Breast Cancer Prostate Cancer Cell Growth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  2. Long W, O’Malley BW (2014) Steroid receptor coactivators (SRCs) as integrators of multiple signaling pathways in cancer progression. In: Kumar R (ed) Nuclear signaling pathways and targeting transcription in cancer. Springer, New YorkGoogle Scholar
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  5. Xu J, Wu RC, O’Malley BW (2009) Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat Rev Cancer 9:615–630PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyWright State UniversityDaytonUSA