Steroid Receptor Coactivators
SRCs are transcriptional coactivators for nuclear hormone receptors (NRs), such as estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR), and for non-NR transcriptional factors, such as Stat3, E2F1, and NFкB.
The common structure of SRC proteins contains five functional domains/regions: the N-terminal basic helix-loop-helix-Per/ARNT/Sim (bHLH/PAS) domain, the serine/threonine-rich (S/T) domain, the nuclear receptor-interacting domain (RID), the CBP (cAMP-response element binding protein)-interacting domain (CID) or activation domain 1 (AD1), and the activation domain 2 (AD2) at the C-terminus. Each domain interacts with different proteins that confer various functions. The bHLH/PAS domain harbors nuclear localization signals (NLS) and is the most...
KeywordsAndrogen Receptor Steroid Receptor Coactivators Receptor Coactivators Cancer Include Breast Cancer Prostate Cancer Cell Growth
- Long W, O’Malley BW (2014) Steroid receptor coactivators (SRCs) as integrators of multiple signaling pathways in cancer progression. In: Kumar R (ed) Nuclear signaling pathways and targeting transcription in cancer. Springer, New YorkGoogle Scholar