Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Mitogen-Activated Protein Kinase Kinase Kinases

  • Bruce D. Cuevas
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7192-1



MAP3K proteins belong to a family of intracellular enzymes in human cells that participate in the regulation of the multiple cellular functions necessary for homeostasis of normal cells and tissues, including control of cellular proliferation, differentiation, apoptosis, and motility. Some of the genes that encode MAP3K proteins have been demonstrated to be mutated in cancers, and chemical agents that selectively inhibit this subset of enzymes are currently used as components of antitumor therapeutic regimens. The human MAP3K gene family consists of more than 20 members (Cuevas et al. 2007); the role of most MAP3K genes in either homeostasis or disease, including cancer, has not yet been fully investigated.


When active, MAP3K proteins initiate the sequential stimulation of at least two other protein kinase enzymes by activating a MAP kinase kinase (MAP2K) that, in turn, activates a MAP kinase (MAPK)...


Mutant BRAF Hairy Cell Leukemia MAPK Protein V600 Mutant BRAF MAP3K Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Molecular Pharmacology and Therapeutics, Stritch School of MedicineLoyola University ChicagoMaywoodUSA