Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Pancreatic Cancer Pathogenesis

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7188-4

Synonyms

Definition

Pancreatic cancer pathogenesis refers to induction and progression of cancer originating from pancreatic cells. Over 95 % of pancreatic tumors are ductal adenocarcinomas. Pancreatic cancer is the fourth leading cause of cancer-associated deaths in the United States (Siegel et al. 2012). The deep-seated anatomical location of pancreas, a lack of clear early symptoms, and high invasiveness of the pancreatic tumor cells cause metastatic spread of the disease even before it is diagnosed. At diagnosis most pancreatic tumors are non-resectable (Hidalgo 2010). Patients undergoing surgical resection face tumor recurrence due to early metastasis. Metastasis often precedes tumor formation, and hence, the genetic alterations in the primary tumors are different from metastases (Rhim et al. 2012). The clinical response to the current therapies is poor, and the 5-year survival rate of the...

Keywords

Pancreatic Cancer Hepatocyte Growth Factor Pancreatic Cancer Cell Pancreatic Tumor Lynch Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.The Eppley Institute for Research in Cancer and Allied Diseases, and Department of Pathology and MicrobiologyUniversity of Nebraska Medical CenterOmahaUSA
  2. 2.The Eppley Institute for Research in Cancer and Allied DiseasesUniversity of Nebraska Medical CenterOmahaUSA
  3. 3.The Eppley Institute for Research in Cancer and Allied Diseases, and Department of Pathology and Microbiology, and Department of Biochemistry and Molecular Biology, and Department of Genetic Cell Biology and AnatomyUniversity of Nebraska Medical CenterOmahaUSA