Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Pancreatic Cancer Development and Regeneration

  • Sonal GuptaEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7186-3


Understanding of progenitor cells and processes for embryonic development of the pancreas and regeneration holds the key for solving mysteries of pancreatic cancer development since many of these pathways are found to be activated in pancreatic tumors. It can also provide clues to regenerate the pancreas following injuries arising from diabetes, pancreatitis, and surgical insult.


Functional Morphology of the Pancreas

On average daily, the pancreas secretes 1,200 ml of pancreatic juice comprising of digestive enzymes necessary for digestion of food and hormones important for blood glucose homeostasis. The pancreas as a glandular organ comprises digestive enzyme-secreting exocrine cells (acinar cells), hormone-secreting endocrine cells (islets of Langerhans), and epithelial duct cells forming a lumen which carries the pancreatic secretions to the common bile duct and intestine.

Endocrine Component

Constituting about 1 % of the adult human pancreas, more than a...


Beta Cell Acinar Cell Secondary Transition Pancreatic Development Intercalate Duct 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Pathology, The Sol Goldman Pancreatic Cancer Research CenterJohns Hopkins University School of MedicineBaltimoreUSA