Pancreatic Cancer Development and Regeneration
Understanding of progenitor cells and processes for embryonic development of the pancreas and regeneration holds the key for solving mysteries of pancreatic cancer development since many of these pathways are found to be activated in pancreatic tumors. It can also provide clues to regenerate the pancreas following injuries arising from diabetes, pancreatitis, and surgical insult.
Functional Morphology of the Pancreas
On average daily, the pancreas secretes 1,200 ml of pancreatic juice comprising of digestive enzymes necessary for digestion of food and hormones important for blood glucose homeostasis. The pancreas as a glandular organ comprises digestive enzyme-secreting exocrine cells (acinar cells), hormone-secreting endocrine cells (islets of Langerhans), and epithelial duct cells forming a lumen which carries the pancreatic secretions to the common bile duct and intestine.
Constituting about 1 % of the adult human pancreas, more than a...