Skip to main content
SpringerLink
Log in
Book cover

Encyclopedia of Cancer pp 1–3Cite as

KDM6

  • Living reference work entry
  • First Online:

  • 76 Accesses

Synonyms

JmjC domain-containing protein 3; JMJD3; Jumonji domain-containing protein 3; KDM6A; KDM6B; KDM6C; Lysine (K)-specific demethylase 6A; Lysine (K)-specific demethylase 6B; Ubiquitous TPR motif protein UTY; Ubiquitously transcribed TPR protein on the X chromosome; Ubiquitously transcribed TPR protein on the Y chromosome; Ubiquitously transcribed X chromosome tetratricopeptide repeat protein; Ubiquitously transcribed Y chromosome tetratricopeptide repeat protein; UTX; UTY, ubiquitously transcribed tetratricopeptide repeat gene on the Y chromosome

Definition

KDM6A and KDM6B are histone demethylases that specifically demethylate the repressive histone 3 (H3) lysine 27 trimethyl mark.

  • KDM6A lysine (K)-specific demethylase 6A; UTX, ubiquitously transcribed TPR protein on the X chromosome; and ubiquitously transcribed X chromosome tetratricopeptide repeat protein

  • KDM6B lysine (K)-specific demethylase 6B; JMJD3; JmjC domain-containing protein 3; and Jumonji domain-containing protein 3

    ...

This is a preview of subscription content, log in via an institution.

References

  • Cloos PA, Christensen J, Agger K, Helin K (2008) Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev 22:111–140

    Article  Google Scholar 

  • Greer EL, Shi Y (2012) Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet 13:343–357

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Swigut T, Wysocka J (2007) H3K27 demethylases, at long last. Cell 131(1):29–32

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Infectious Diseases, Brigham and Womens Hospital, Boston, MA, USA

    Margaret McLaughlin-Drubin

Authors
  1. Margaret McLaughlin-Drubin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Margaret McLaughlin-Drubin .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

McLaughlin-Drubin, M. (2014). KDM6. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7177-3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-27841-9_7177-3

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation