Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

KDM6

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7177-3

Synonyms

Definition

KDM6A and KDM6B are histone demethylases that specifically demethylate the repressive histone 3 (H3) lysine 27 trimethyl mark.
  • KDM6A lysine (K)-specific demethylase 6A; UTX, ubiquitously transcribed TPR protein on the X chromosome; and ubiquitously transcribed X chromosome tetratricopeptide repeat protein

  • KDM6B lysine (K)-specific demethylase 6B; JMJD3; JmjC domain-containing protein 3; and Jumonji domain-containing protein 3

  • K...

Keywords

Transcriptional Start Site Embryonic Stem Cell Differentiation Tetratricopeptide Repeat Mesoderm Differentiation Bivalent Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Cloos PA, Christensen J, Agger K, Helin K (2008) Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev 22:111–140CrossRefGoogle Scholar
  2. Greer EL, Shi Y (2012) Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet 13:343–357PubMedCentralCrossRefPubMedGoogle Scholar
  3. Swigut T, Wysocka J (2007) H3K27 demethylases, at long last. Cell 131(1):29–32CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Division of Infectious DiseasesBrigham and Womens HospitalBostonUSA