Steroid X Receptor (SXR)
Steroid X receptor (SXR) is a ligand-dependent transcription factor that belongs to the nuclear receptor superfamily. SXR is a promiscuous orphan nuclear receptor as it is activated by a broad range of endobiotics and xenobiotics, including anticancer drugs. The major function of SXR is to sense the presence of toxic substances in the body and in response upregulate the expression of drug metabolizing and transport proteins, such as cytochrome P450 3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1), respectively, to detoxify and clear these substances from the body. However, recent evidence supports that SXR promotes cancer growth and progression by regulating cell proliferation, migration, and death. In addition, SXR contributes to anticancer drug resistance primarily by upregulating the expression of proteins involved in the metabolism and transport of anticancer drugs.
KeywordsOvarian Cancer Endometrial Cancer Human Colon Cancer Cell Human Prostate Cancer Cell Cancer Drug Resistance
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