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Glioblastoma Therapy

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 97 Accesses

Synonyms

GBM therapy; Glioblastoma Multiforme Therapy

Definition

Glioblastoma (GBM) therapy refers to the treatment regimen for patients suffering from this highly aggressive and lethal brain tumor. The current standard of care for GBM is maximal surgical resection followed by radiation therapy and chemotherapy with temozolomide, a DNA alkylating agent. Despite technological advances in both surgical techniques and chemotherapeutic drugs, recurrence of GBM is almost a certainty. Therefore, for the majority of GBM patients, therapy is merely palliative. Research is actively underway to identify innovative new therapeutic strategies and more effective therapeutic compounds to improve GBM therapy.

Characteristics

Current Treatment Regimen

Current treatment regimens for GBMs involve targeting one of the hallmarks of GBM tumors through a combination of surgery, radiation, and intravenously delivered chemotherapeutic drugs. Surgery is the first step of treatment in glioblastoma. Removal of...

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References

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Author information

Authors and Affiliations

  1. Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA

    Shawn Hingtgen

Authors
  1. Shawn Hingtgen
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Corresponding author

Correspondence to Shawn Hingtgen .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2014 Springer-Verlag Berlin Heidelberg

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Hingtgen, S. (2014). Glioblastoma Therapy. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7171-5

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_7171-5

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

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