Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Activin Receptors

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7170-5

Synonyms

Definition

Activin receptors are transmembrane serine threonine kinases that bind activins and subsequently trigger an intracellular signaling cascade. There are two types of activin receptors designated as type I and type II. Activins first bind type II receptors, whereupon type I receptors are recruited into the complex, which leads to the phosphorylation of intracellular signaling mediators called Smads. In a wider sense, however, the term activin receptor-like kinase (ALK) is also used for the structurally related type I receptors that transmit signals from other cytokines of the transforming growth factor beta (TGFβ) family including TGFβ itself, bone morphogenetic proteins (BMP), myostatin, growth and differentiation factors (GDF), and Müllerian inhibitory substance (MIS). Confusingly, the abbreviation ALK is also used for anaplastic lymphoma kinase– a...

Keywords

Anaplastic Lymphoma Kinase Cancer Cachexia Serine Threonine Kinase Tumor Suppressive Effect Activin Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Cunha SI, Pietras K (2011) ALK1 as an emerging target for antiangiogenic therapy of cancer. Blood 117:6999–7006CrossRefPubMedPubMedCentralGoogle Scholar
  2. Hinck AP (2012) Structural studies of the TGF-betas and their receptors – insights into evolution of the TGF-beta superfamily. FEBS Lett 586:1860–1870CrossRefPubMedGoogle Scholar
  3. Jung B, Doctolero RT, Tajima A, Nguyen AK, Keku T, Sandler RS, Carethers JM (2004) Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers. Gastroenterology 126:654–659CrossRefPubMedGoogle Scholar
  4. Tsuchida K, Nakatani M, Uezumi A, Murakami T, Cui X (2008) Signal transduction pathway through activin receptors as a therapeutic target of musculoskeletal diseases and cancer. Endocr J 55:11–21CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Institute of Cancer Research, Department of Medicine IMedical University of ViennaViennaAustria
  2. 2.Division of Thoracic SurgeryMedical University of ViennaViennaAustria