Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Oncology Models in Mice

  • Dawn Waterhouse
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7168-3

Definition

Experimental model systems in which mice either have cancer cells introduced by inoculation or implantation or are genetically or chemically altered so as to spontaneously develop tumors. These model systems may be used to test hypothesis around onset, progression, and molecular basis of the disease and to test novel therapeutics either as single agents or in combination. The use of mice offers several advantages including rapid reproduction with large litters, inexpensive maintenance as compared to other animals, as well as the ability to introduce defined genetic alterations. Moreover, there are extensive physiological and molecular similarities to humans. However, there are important drawbacks to the use of mice including the obvious species-specific differences between mice and human, differences in metabolism and drug affinity to target proteins, and differences in tumor homogeneity. These differences must be considered when using mouse model systems in oncology.

Characteristics...

Keywords

Mouse Mammary Tumor Virus Inducible System Whey Acidic Protein Engraftment Rate Digestive System Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Cheon DJ, Orsulic S (2011) Mouse models of cancer. Annu Rev Pathol Mech Dis 6:95–119CrossRefGoogle Scholar
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  3. Waterhouse DN, Gelmon K, Klasa R, Chi K, Huntsman D, Ramsay E, Wasan E, Edwards L, Tucker C, Zastre J, Wang YZ, Yapp D, Dragowska W, Dunn S, Dedhar S, Bally B (2006) Development and assessment of conventional and targeted drug combinations for use in the treatment of aggressive breast cancers. Curr Cancer Drug Targets 6:455–489CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Experimental TherapeuticsBC Cancer AgencyVancouverCanada