Oncology Models in Mice
Experimental model systems in which mice either have cancer cells introduced by inoculation or implantation or are genetically or chemically altered so as to spontaneously develop tumors. These model systems may be used to test hypothesis around onset, progression, and molecular basis of the disease and to test novel therapeutics either as single agents or in combination. The use of mice offers several advantages including rapid reproduction with large litters, inexpensive maintenance as compared to other animals, as well as the ability to introduce defined genetic alterations. Moreover, there are extensive physiological and molecular similarities to humans. However, there are important drawbacks to the use of mice including the obvious species-specific differences between mice and human, differences in metabolism and drug affinity to target proteins, and differences in tumor homogeneity. These differences must be considered when using mouse model systems in oncology.
KeywordsMouse Mammary Tumor Virus Inducible System Whey Acidic Protein Engraftment Rate Digestive System Cancer
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