Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Antiviral Defenses

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7161-5

Definition

The biological mechanisms of living hosts and individual cells to limit virus infection and replication.

Characteristics

Individual cells in all kingdoms of life, including bacteria and other unicellular organisms, as well as plants and animals have evolved mechanisms to ward of virus infection and to restrict virus dissemination between and within cells. These antiviral defenses operate either through intracellular mechanisms or through the action of other cells or extracellular molecules, such as cells of the immune system and antibodies.

Evolution

Several theories on the origin of life have been presented. Irrespective of molecular causality, most theories eventually converge on the emergence of compartmentalized life to provide self-replicating information an advantage in a hostile environment. Paralleling emergence of the first cells, viruses likely exerted evolutionary pressure necessitating means to restrict excessive and self-annihilating replication. On one hand,...

Keywords

Influenza Virus Oncolytic Virus Japanese Encephalitis Virus Antiviral Defense Interferon Stimulate Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Diallo JS, Le Boeuf F, Lai F, Cox J, Vähä-Koskela M, Abdelbary H, MacTavish H, Waite K, Falls T, Wang J, Brown R, Blanchard JE, Brown ED, Kirn DH, Hiscott J, Atkins H, Lichty BD, Bell JC (2010) A high-throughput pharmacoviral approach identifies novel oncolytic virus sensitizers. Mol Ther 18:1123–1129PubMedCentralCrossRefPubMedGoogle Scholar
  2. Haller O, Kochs G, Weber F (2006) The interferon response circuit: induction and suppression by pathogenic viruses. Virology 5:119–130CrossRefGoogle Scholar
  3. Isaacs A, Lindemann J (1957) Virus interference. I. The interferon. Proc R Soc Lond B Biol Sci 12:258–267CrossRefGoogle Scholar
  4. Kanneganti TD (2010) Central roles of NLRs and inflammasomes in viral infection. Nat Rev Immunol 10:688–698PubMedCentralCrossRefPubMedGoogle Scholar
  5. Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y, Fujita T, Akira S (2006) Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 4:101–105CrossRefGoogle Scholar
  6. Müller U, Steinhoff U, Reis LF, Hemmi S, Pavlovic J, Zinkernagel RM, Aguet M (1994) Functional role of type I and type II interferons in antiviral defense. Science 24:1918–1921CrossRefGoogle Scholar
  7. Nagano Y, Kojima Y (1954) Immunizing property of vaccinia virus inactivated by ultraviolets rays [Article in French]. C R Seances Soc Biol Fil 148:1700–1702PubMedGoogle Scholar
  8. Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, Rice CM (2011) A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 28:481–485CrossRefGoogle Scholar
  9. Shin EC, Seifert U, Kato T, Rice CM, Feinstone SM, Kloetzel PM, Rehermann B (2006) Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection. J Clin Invest 116:3006–3014PubMedCentralCrossRefPubMedGoogle Scholar
  10. Stojdl DF, Lichty B, Knowles S, Marius R, Atkins H, Sonenberg N, Bell JC (2000) Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Nat Med 6:821–825CrossRefPubMedGoogle Scholar
  11. Villarreal L (2011) Viral ancestors of antiviral systems. Viruses 3:1933–1958PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Molecular Cancer Biology Research ProgramUniversity of HelsinkiHelsinkiFinland