Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

WIPI

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7160-4

Synonyms

Definition

The WIPI (WD-repeat proteins Interacting with PhosphoInositides) protein family is an evolutionarily highly conserved 7-bladed beta-propeller protein family, commonly binding to particular phosphoinositides, PtdIns(3)P (phosphatidylinositol 3-phosphate) and PtdIns(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) (Proikas-Cezanne et al. 2004). Yeast (Atg18) and human (WIPI-1, WIPI-2, WIPI-4) members have been found to function as essential phosphoinositide effectors in autophagy (Stromhaug et al. 2004; Proikas-Cezanne et al. 2007), a lysosomal degradation mechanism that secures cellular survival in both normal and tumor cells (Mizushima et al. 2008). The specific localization of WIPI-1 at autophagosomal membranes is used to monitor the process of autophagy in cancer cells (Proikas-Cezanne and Pfisterer 2009).

Characteristics

  • Ancient 7-bladed beta-propeller protein family with two paralogous groups, one...

Keywords

Autophagosome Formation Autophagy Induction Autophagic Activity Autophagic Degradation Cytoplasmic Material 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  3. Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451:1069–1075CrossRefPubMedPubMedCentralGoogle Scholar
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  5. Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A et al (2004) WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy. Oncogene 23:9314–9325CrossRefPubMedGoogle Scholar
  6. Proikas-Cezanne T, Ruckerbauer S, Stierhof YD, Berg C, Nordheim A (2007) Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy. FEBS Lett 581:3396–3404CrossRefPubMedGoogle Scholar
  7. Stromhaug PE, Reggiori F, Guan J, Wang CW, Klionsky DJ (2004) Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy. Mol Biol Cell 15:3553–3566CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute for Cell Biology, Faculty of ScienceEberhard Karls University TübingenTübingenGermany