Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Tassula Proikas-Cezanne
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7160-4



The WIPI (WD-repeat proteins Interacting with PhosphoInositides) protein family is an evolutionarily highly conserved 7-bladed beta-propeller protein family, commonly binding to particular phosphoinositides, PtdIns(3)P (phosphatidylinositol 3-phosphate) and PtdIns(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) (Proikas-Cezanne et al. 2004). Yeast (Atg18) and human (WIPI-1, WIPI-2, WIPI-4) members have been found to function as essential phosphoinositide effectors in autophagy (Stromhaug et al. 2004; Proikas-Cezanne et al. 2007), a lysosomal degradation mechanism that secures cellular survival in both normal and tumor cells (Mizushima et al. 2008). The specific localization of WIPI-1 at autophagosomal membranes is used to monitor the process of autophagy in cancer cells (Proikas-Cezanne and Pfisterer 2009).


  • Ancient 7-bladed beta-propeller protein family with two paralogous groups, one...


Autophagosome Formation Autophagy Induction Autophagic Activity Autophagic Degradation Cytoplasmic Material 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute for Cell Biology, Faculty of ScienceEberhard Karls University TübingenTübingenGermany