The MAGEA11 gene codes for melanoma antigen-A11 (MAGE-11), a cancer-testis antigen in the MAGEA gene subfamily at Xq28 on the human X chromosome. MAGE-11 is a primate-specific coregulator that interacts with multiple transcriptional regulatory proteins to increase steroid hormone-regulated gene transcription. MAGE-11 increases androgen-dependent and androgen-independent gene expression by the human androgen receptor (AR) and human progesterone receptor isoform B (PR-B) through interactions with p160 coactivators, the p300 acetyltransferase and the FK506 binding protein 5 (FKBP5 known also as FKBP51). MAGE-11 appears to function in a transcriptional hub to amplify steroid hormone-regulated gene transcription in human and nonhuman primates.
KeywordsAndrogen Receptor Prostate Cancer Progression Androgen Receptor Activation Human Androgen Receptor P160 Coactivator
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