Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

MAGE-A11

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7159-4

Synonyms

Definition

The MAGEA11 gene codes for melanoma antigen-A11 (MAGE-11), a cancer-testis antigen in the MAGEA gene subfamily at Xq28 on the human X chromosome. MAGE-11 is a primate-specific coregulator that interacts with multiple transcriptional regulatory proteins to increase steroid hormone-regulated gene transcription. MAGE-11 increases androgen-dependent and androgen-independent gene expression by the human androgen receptor (AR) and human progesterone receptor isoform B (PR-B) through interactions with p160 coactivators, the p300 acetyltransferase and the FK506 binding protein 5 (FKBP5 known also as FKBP51). MAGE-11 appears to function in a transcriptional hub to amplify steroid hormone-regulated gene transcription in human and nonhuman primates.

Characteristics

MAGE-11 Protein

MAGE-11 was...

Keywords

Androgen Receptor Prostate Cancer Progression Androgen Receptor Activation Human Androgen Receptor P160 Coactivator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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See Also

  1. (2012) Cancer Testis Antigens. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin/Heidelberg, p 630. doi: 10.1007/978-3-642-16483-5_817Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Pediatrics and Biochemistry and BiophysicsUniversity of North Carolina at Chapel HillChapel HillUSA