Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Elizabeth M. Wilson
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7159-4



The MAGEA11 gene codes for melanoma antigen-A11 (MAGE-11), a cancer-testis antigen in the MAGEA gene subfamily at Xq28 on the human X chromosome. MAGE-11 is a primate-specific coregulator that interacts with multiple transcriptional regulatory proteins to increase steroid hormone-regulated gene transcription. MAGE-11 increases androgen-dependent and androgen-independent gene expression by the human androgen receptor (AR) and human progesterone receptor isoform B (PR-B) through interactions with p160 coactivators, the p300 acetyltransferase and the FK506 binding protein 5 (FKBP5 known also as FKBP51). MAGE-11 appears to function in a transcriptional hub to amplify steroid hormone-regulated gene transcription in human and nonhuman primates.


MAGE-11 Protein

MAGE-11 was...


Androgen Receptor Prostate Cancer Progression Androgen Receptor Activation Human Androgen Receptor P160 Coactivator 
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See Also

  1. (2012) Cancer Testis Antigens. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin/Heidelberg, p 630. doi: 10.1007/978-3-642-16483-5_817Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Pediatrics and Biochemistry and BiophysicsUniversity of North Carolina at Chapel HillChapel HillUSA