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Definition
The evidence-based combination of therapeutic interventions to optimize the mechanistic spectrum and specificity of cancer therapy to achieve effective tumor clearance, prevent recurrence and minimize off-target cytotoxicity.
Characteristics
Introduction
A tumor in any part of the body can be characterized by six classical hallmarks.
Self-sufficiency in growth signals
Insensitivity to antigrowth signals
Limitless potential for cell division
Evasion of apoptosis or resistance to cell death
Sustained angiogenesis or the ability to form blood vessels
Tissue invasion and metastasis, or distant spread
These hallmark features collectively differentiate the tumor from its normal surrounding tissues. Hence, the initial interventional approaches were aimed at targeting these hallmarks in cancers or inhibiting the expression and activity of individual molecules that contribute to acquisition and maintenance of one or more of these six hallmarks in...
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References
Arrigo S et al (1990) Better survival after combined modality care for adults with Wilms’ tumor. A report from the National Wilms’ Tumor Study. Cancer 66:827–830
Awasthi S et al (2000) Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin. Biochemistry 39:9327–9334
Bonadonna G et al (1995) Sequential or alternating doxorubicin and CMF regimens in breast cancer with more than three positive nodes. Ten-year results. JAMA 273:542–547
Devita VT et al (2008) DeVita, Hellman, and Rosenberg’s cancer: principles & practice of oncology, 8th edn. Lippincott Williams & Wilkins, Philadelphia
Goudar RK et al (2005) Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Mol Cancer Ther 4:101–112
Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70
Paternot S, Roger PP (2009) Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation. Cancer Res 69:4577–4581
See Also
(2012) Cell Death. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 737. doi: 10.1007/978-3-642-16483-5_6724
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Dalasanur Nagaprashantha, L. (2014). Combinatorial Cancer Therapy. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7158-7
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DOI: https://doi.org/10.1007/978-3-642-27841-9_7158-7
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Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
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