Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Neuroprotection

  • Donat Kögel
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7153-2

Definition

Neuroprotection is the active suppression of damaging neurotoxic conditions in the nervous system in an aim to inhibit apoptosis, neuronal dysfunction, and neurodegeneration of nerve cells. This may be either achieved by endogenous neuroprotectants or by exogenously added pharmacological agents/neuroprotective therapies. Neuroprotective therapies are currently clinically developed both for acute (e.g., stroke) and chronic forms of CNS damage (e.g., Alzheimer’s disease). In the context of cancer, neuroprotective strategies aim at limiting the often severe neurotoxic side effects of chemotherapy/radiotherapy without affecting the antitumor efficacy of antineoplastic therapies. In addition to the obvious benefits in the quality of life, this may also allow to delay premature termination of cancer treatment and thereby improve the clinical outcome.

Characteristics

Several chemotherapeutic agents are known to have severe neurotoxic activity, and peripheral neuropathy is one of...

Keywords

Peripheral Neuropathy Antineoplastic Therapy Vinca Alkaloid Glutamate Receptor Antagonist Target Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Buckingham SC, Campbell SL, Haas BR, Montana V, Robel S, Ogunrinu T, Sontheimer H (2011) Glutamate release by primary brain tumors induces epileptic activity. Nat Med 17:1269–1274PubMedCentralCrossRefPubMedGoogle Scholar
  2. Schiff D, Wen PY, van den Bent MJ (2009) Neurological adverse effects caused by cytotoxic and targeted therapies. Nat Rev 6:596–603Google Scholar
  3. Walker M, Ni O (2007) Neuroprotection during chemotherapy: a systematic review. Am J Clin Oncol 30:82–92CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Experimental Neurosurgery, Center for Neurology and NeurosurgeryGoethe-University HospitalFrankfurt am MainGermany