Endocrine Therapy in Breast Cancer
Endocrine therapy in breast cancer is one of the earliest targeted therapy developed for cancer and is used to treat estrogen receptor alpha (ERα)-positive breast tumors that depend on estrogens for their growth. It works by blocking estrogen signaling through two main modalities: (1) targeting the ERα protein and (2) depriving cancer cells of estrogen supply either by ovarian suppression in premenopausal women or by inhibition of extraovarian estrogen production in postmenopausal women. Endocrine therapy is currently used both in early-stage as well as in advanced/metastatic breast cancer.
ERα-positive (ERα+) breast cancer accounts for approximately 70 % of all breast cancers and is typically characterized by positivity for progesterone receptor (PgR) expression, less frequent amplification/overexpression of human epidermal growth factor receptor 2...
KeywordsBreast Cancer Epidermal Growth Factor Receptor Endometrial Cancer Premenopausal Woman Ovarian Suppression
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